SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 8 GLU A  27
ALA A 113
LEU A  30
ALA A  67
THR A  63
 None
 1.33A 1ie4B-2hyjA:
undetectable
1ie4D-2hyjA:
undetectable		 1ie4B-2hyjA:
19.14
1ie4D-2hyjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 VAL A 129
LEU A 110
LEU A  64
LEU A  59
GLU A 117
 None
 1.18A 1mmkA-2hyjA:
undetectable		 1mmkA-2hyjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 VAL A 129
LEU A 110
LEU A  64
LEU A  59
GLU A 117
 None
 1.14A 1mmtA-2hyjA:
undetectable		 1mmtA-2hyjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 LEU A  30
ALA A  21
VAL A  49
ILE A  33
 None
 0.66A 3wsjB-2hyjA:
undetectable		 3wsjB-2hyjA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 144
ALA A  79
TRP A  72
SER A  96
LEU A 171
 None
 1.49A 4iarA-2hyjA:
3.0		 4iarA-2hyjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ASP A 149
GLY A  85
PRO A  84
GLN A 139
 None
 1.31A 4oltA-2hyjA:
0.0		 4oltA-2hyjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 ALA A 114
GLY A  29
LEU A  30
LEU A  64
 None
 0.80A 4po0A-2hyjA:
4.3		 4po0A-2hyjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A  86
ALA A 147
LEU A 144
ALA A 196
ILE A 166
 None
 1.11A 5itzB-2hyjA:
undetectable		 5itzB-2hyjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ILE A  33
PHE A  53
SER A  62
ALA A  21
 None
 1.14A 5msdA-2hyjA:
undetectable		 5msdA-2hyjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A  86
LEU A 153
ILE A 193
ALA A 162
LEU A 140
 None
 1.06A 5og9B-2hyjA:
undetectable		 5og9B-2hyjA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 LEU A 197
ALA A 198
LEU A  86
 None
 0.44A 5uunB-2hyjA:
undetectable		 5uunB-2hyjA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ALA A 169
ALA A 172
ALA A 189
ALA A 192
 None
 0.81A 6gtqA-2hyjA:
0.2
6gtqB-2hyjA:
0.2		 6gtqA-2hyjA:
23.77
6gtqB-2hyjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ALA A 189
ALA A 192
ALA A 169
ALA A 172
 None
 0.81A 6gtqA-2hyjA:
0.2
6gtqB-2hyjA:
0.2		 6gtqA-2hyjA:
23.77
6gtqB-2hyjA:
23.77