SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 PHE A 147
TRP A 118
GLU A 123
 None
GOL  A 250 ( 4.0A)
GOL  A 250 ( 3.0A)
 1.10A 1mogA-2hykA:
undetectable		 1mogA-2hykA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 ASP A 237
ASP A  13
ASN A  57
 CA  A 477 ( 3.3A)
None
None
 0.84A 2bm9D-2hykA:
undetectable		 2bm9D-2hykA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 6 ASN A  51
SER A  52
HIS A  30
ASP A  47
 None
None
EOH  A 246 ( 4.1A)
None
 1.27A 3aruA-2hykA:
undetectable		 3aruA-2hykA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 4 SER A 227
GLY A 226
GLY A  99
GLY A 101
 None
 0.81A 3bogB-2hykA:
undetectable
3bogD-2hykA:
undetectable		 3bogB-2hykA:
undetectable
3bogD-2hykA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 4 VAL A 236
PHE A 168
PHE A 164
VAL A 137
 None
 1.25A 3rv5C-2hykA:
undetectable
3rv5D-2hykA:
undetectable		 3rv5C-2hykA:
15.92
3rv5D-2hykA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		5 / 12 GLY A 222
ASP A 219
ILE A 102
ASN A  40
SER A  74
 None
 1.25A 4pooA-2hykA:
undetectable		 4pooA-2hykA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 7 MET A 127
GLU A 128
GLU A  41
ARG A  76
 None
GOL  A 249 ( 3.1A)
None
None
 1.27A 4r87J-2hykA:
undetectable
4r87L-2hykA:
undetectable		 4r87J-2hykA:
19.18
4r87L-2hykA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 GLU A  14
TYR A 242
GLU A  91
 None
 0.84A 4ryaA-2hykA:
undetectable		 4ryaA-2hykA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 ASP A 237
GLY A  58
ASP A  55
 CA  A 477 ( 3.3A)
CA  A 477 ( 3.8A)
None
 0.65A 4xdtA-2hykA:
undetectable		 4xdtA-2hykA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 TYR A 192
THR A 181
THR A 193
 None
None
SO4  A 251 ( 2.7A)
 0.81A 5aoxB-2hykA:
undetectable		 5aoxB-2hykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		3 / 3 TYR A 192
THR A 181
THR A 193
 None
None
SO4  A 251 ( 2.7A)
 0.81A 5aoxE-2hykA:
undetectable		 5aoxE-2hykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		5 / 12 HIS A 142
ARG A 132
GLY A 222
GLY A 149
GLY A 148
 GOL  A 249 ( 4.1A)
None
None
None
GOL  A 250 ( 3.4A)
 0.99A 6brdB-2hykA:
undetectable		 6brdB-2hykA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 7 ASP A  47
THR A  46
TYR A  45
LEU A  77
 None
 1.17A 6nmfA-2hykA:
undetectable
6nmfC-2hykA:
undetectable
6nmfP-2hykA:
undetectable		 6nmfA-2hykA:
19.25
6nmfC-2hykA:
20.59
6nmfP-2hykA:
20.59