SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 TRP A 166
ALA A 163
LEU A  96
LEU A 188
ALA A 182
None
0.86A 1h9zA-2hytA:
3.2
1h9zA-2hytA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 TRP A 166
ALA A 163
LEU A  96
LEU A 188
ALA A 182
None
0.86A 1ha2A-2hytA:
3.8
1ha2A-2hytA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 12 SER A 159
TYR A 157
TYR A  95
LEU A 188
PHE A  88
None
None
EDO  A 197 (-4.2A)
None
None
1.32A 1vpoH-2hytA:
undetectable
1vpoL-2hytA:
undetectable
1vpoH-2hytA:
20.96
1vpoL-2hytA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
4 / 8 LEU A 152
ILE A 156
LEU A 138
ILE A 139
None
0.94A 2azxA-2hytA:
undetectable
2azxA-2hytA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
3 / 3 PHE A  88
SER A 159
LEU A 155
None
0.83A 2w1bA-2hytA:
undetectable
2w1bA-2hytA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 12 ILE A 107
ARG A 113
ALA A 168
ALA A 114
ILE A 104
None
None
None
None
EDO  A 199 (-4.9A)
1.10A 3jb1A-2hytA:
undetectable
3jb1A-2hytA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
4 / 7 ALA A 114
TYR A  29
ARG A 106
ALA A  30
None
1.11A 3twpB-2hytA:
undetectable
3twpB-2hytA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ALA A  60
GLY A 117
GLY A 118
ASP A  67
SER A 123
None
1.04A 4qvlY-2hytA:
undetectable
4qvlZ-2hytA:
undetectable
4qvlY-2hytA:
18.18
4qvlZ-2hytA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ALA A  60
GLY A 117
GLY A 118
ASP A  67
SER A 123
None
1.04A 4qvwK-2hytA:
undetectable
4qvwL-2hytA:
undetectable
4qvwK-2hytA:
18.64
4qvwL-2hytA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ALA A  60
GLY A 117
GLY A 118
ASP A  67
SER A 123
None
1.04A 4qvwY-2hytA:
undetectable
4qvwZ-2hytA:
undetectable
4qvwY-2hytA:
18.64
4qvwZ-2hytA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ALA A  60
GLY A 117
GLY A 118
ASP A  67
SER A 123
None
1.02A 4qw1K-2hytA:
undetectable
4qw1L-2hytA:
undetectable
4qw1K-2hytA:
18.18
4qw1L-2hytA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
4 / 8 ALA A 163
ALA A 164
ILE A 167
LEU A 100
None
0.58A 4v1fA-2hytA:
undetectable
4v1fB-2hytA:
undetectable
4v1fA-2hytA:
20.63
4v1fB-2hytA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ALA A  60
GLY A 117
GLY A 118
ASP A  67
SER A 123
None
1.04A 5bxnY-2hytA:
undetectable
5bxnZ-2hytA:
undetectable
5bxnY-2hytA:
18.18
5bxnZ-2hytA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
3 / 3 ASP A  67
ARG A 133
ARG A  91
None
None
EDO  A 197 (-4.0A)
0.94A 5eajB-2hytA:
undetectable
5eajB-2hytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.24A 6dlzA-2hytA:
undetectable
6dlzD-2hytA:
2.0
6dlzA-2hytA:
14.78
6dlzD-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 LEU A 160
LEU A  74
ASP A  71
ILE A 156
SER A 130
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
None
None
1.21A 6dlzB-2hytA:
2.0
6dlzC-2hytA:
undetectable
6dlzB-2hytA:
14.78
6dlzC-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.17A 6dlzB-2hytA:
2.0
6dlzC-2hytA:
undetectable
6dlzB-2hytA:
14.78
6dlzC-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
None
None
None
EDO  A 197 ( 4.8A)
None
1.23A 6dlzB-2hytA:
2.0
6dlzC-2hytA:
undetectable
6dlzB-2hytA:
14.78
6dlzC-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ILE A 156
SER A 130
LEU A 160
LEU A  74
ASP A  71
None
None
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
1.22A 6dlzA-2hytA:
undetectable
6dlzD-2hytA:
2.0
6dlzA-2hytA:
14.78
6dlzD-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
None
None
None
EDO  A 197 ( 4.8A)
None
1.15A 6dlzA-2hytA:
undetectable
6dlzD-2hytA:
2.0
6dlzA-2hytA:
14.78
6dlzD-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 9 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.23A 6dm0A-2hytA:
undetectable
6dm0D-2hytA:
2.1
6dm0A-2hytA:
14.78
6dm0D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.21A 6dm0B-2hytA:
2.0
6dm0C-2hytA:
undetectable
6dm0B-2hytA:
14.78
6dm0C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 9 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
None
None
None
EDO  A 197 ( 4.8A)
None
1.23A 6dm0B-2hytA:
2.0
6dm0C-2hytA:
undetectable
6dm0B-2hytA:
14.78
6dm0C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.24A 6dm1A-2hytA:
undetectable
6dm1D-2hytA:
2.0
6dm1A-2hytA:
14.78
6dm1D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 LEU A 160
LEU A  74
ASP A  71
ILE A 156
SER A 130
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
None
None
1.22A 6dm1B-2hytA:
undetectable
6dm1C-2hytA:
undetectable
6dm1B-2hytA:
14.78
6dm1C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
None
EDO  A 197 ( 4.8A)
None
None
None
1.17A 6dm1B-2hytA:
undetectable
6dm1C-2hytA:
undetectable
6dm1B-2hytA:
14.78
6dm1C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
None
None
None
EDO  A 197 ( 4.8A)
None
1.24A 6dm1B-2hytA:
undetectable
6dm1C-2hytA:
undetectable
6dm1B-2hytA:
14.78
6dm1C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ILE A 156
SER A 130
LEU A 160
LEU A  74
ASP A  71
None
None
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
1.21A 6dm1A-2hytA:
undetectable
6dm1D-2hytA:
2.0
6dm1A-2hytA:
14.78
6dm1D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 11 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
None
None
None
EDO  A 197 ( 4.8A)
None
1.16A 6dm1A-2hytA:
undetectable
6dm1D-2hytA:
2.0
6dm1A-2hytA:
14.78
6dm1D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 LEU A 160
LEU A  74
ASP A  71
ILE A 156
SER A 130
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
None
None
1.22A 6dm2B-2hytA:
2.0
6dm2C-2hytA:
2.3
6dm2B-2hytA:
14.78
6dm2C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum)
5 / 10 ILE A 156
SER A 130
LEU A 160
LEU A  74
ASP A  71
None
None
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
1.21A 6dm2A-2hytA:
undetectable
6dm2D-2hytA:
2.1
6dm2A-2hytA:
14.78
6dm2D-2hytA:
14.78