SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 GLU A 102
ALA A 106
LEU A  92
ALA A 109
GLY A 113
 None
 1.06A 1mjqG-2hz2A:
undetectable
1mjqH-2hz2A:
undetectable		 1mjqG-2hz2A:
22.76
1mjqH-2hz2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 ALA A  17
ALA A  54
ALA A 112
VAL A  87
 None
None
None
HEM  A 125 (-4.8A)
 0.89A 2nyrB-2hz2A:
undetectable		 2nyrB-2hz2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A  95
LEU A  91
ALA A 112
ALA A  54
 None
 0.85A 6a7jA-2hz2A:
undetectable		 6a7jA-2hz2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A  63
ASP A 120
ARG A  64
ARG A  67
 CD  A 202 ( 4.4A)
CD  A 202 (-2.2A)
None
None
 1.24A 6dwdB-2hz2A:
undetectable
6dwdD-2hz2A:
undetectable		 6dwdB-2hz2A:
14.25
6dwdD-2hz2A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 ARG A  64
ARG A  67
GLY A  63
ASP A 120
 None
None
CD  A 202 ( 4.4A)
CD  A 202 (-2.2A)
 1.23A 6dwjB-2hz2A:
undetectable
6dwjD-2hz2A:
1.7		 6dwjB-2hz2A:
14.25
6dwjD-2hz2A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2hz2 CYANOGLOBIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A  94
VAL A 108
ASP A  19
PHE A  21
VAL A  14
 None
 1.44A 6iblA-2hz2A:
undetectable		 6iblA-2hz2A:
15.29