SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT
(Homo
sapiens) 		4 / 5 SER A  41
PRO A 225
TYR A 289
VAL A 226
 None
 1.36A 3sufC-2hz6A:
0.4		 3sufC-2hz6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT
(Homo
sapiens) 		3 / 3 SER A 298
ASP A  76
ASP A 181
 None
 0.91A 3uj7A-2hz6A:
undetectable		 3uj7A-2hz6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT
(Homo
sapiens) 		5 / 12 ILE A 100
ALA A 177
TYR A 117
LEU A 103
LEU A  96
 None
 1.45A 4qztC-2hz6A:
2.1		 4qztC-2hz6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT
(Homo
sapiens) 		4 / 4 VAL A 240
LYS A 239
VAL A 226
ASN A 244
 None
 1.32A 5vc3A-2hz6A:
undetectable		 5vc3A-2hz6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT
(Homo
sapiens) 		5 / 12 ILE A 100
ASN A 176
LEU A  85
PRO A  75
LEU A  82
 None
 1.22A 5xxiA-2hz6A:
undetectable		 5xxiA-2hz6A:
22.06