SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 MET A 106
SER A 121
ALA A 123
ILE A 122
 None
 1.15A 1gm7A-2hz7A:
undetectable
1gm7B-2hz7A:
undetectable		 1gm7A-2hz7A:
13.48
1gm7B-2hz7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 MET A 106
SER A 121
ALA A 123
ILE A 122
 None
 1.17A 1pnlA-2hz7A:
undetectable
1pnlB-2hz7A:
undetectable		 1pnlA-2hz7A:
13.48
1pnlB-2hz7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 THR A 495
LEU A 496
ILE A 476
VAL A 468
LEU A 440
 None
 0.76A 1wsvA-2hz7A:
undetectable		 1wsvA-2hz7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 THR A 495
LEU A 496
ILE A 476
VAL A 468
LEU A 440
 None
 0.77A 1wsvB-2hz7A:
undetectable		 1wsvB-2hz7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 ALA A  95
LEU A  90
ASP A 132
GLY A  99
ASP A  91
 None
 1.15A 2f8lA-2hz7A:
undetectable		 2f8lA-2hz7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 4 LEU A 376
ALA A 346
VAL A 347
PRO A 344
 None
 1.23A 3gv1B-2hz7A:
undetectable		 3gv1B-2hz7A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 PRO A 332
LEU A  82
GLN A 337
 None
 0.73A 3hznG-2hz7A:
undetectable
3hznH-2hz7A:
undetectable		 3hznG-2hz7A:
14.60
3hznH-2hz7A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 11 VAL A  47
TYR A  98
ILE A 354
PHE A 299
ILE A  52
 None
 1.48A 3q5rA-2hz7A:
0.0		 3q5rA-2hz7A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 VAL A 392
LEU A 497
LEU A 394
GLY A 465
ALA A 478
 None
 1.00A 3rr3C-2hz7A:
undetectable		 3rr3C-2hz7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 VAL A 392
LEU A 497
LEU A 394
GLY A 465
ALA A 478
 None
 1.00A 3rr3D-2hz7A:
undetectable		 3rr3D-2hz7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ALA A 385
TYR A 595
ARG A 382
ARG A 436
 None
 1.10A 3twpA-2hz7A:
2.3		 3twpA-2hz7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ALA A 385
TYR A 595
ARG A 382
ARG A 436
 None
 1.08A 3twpB-2hz7A:
2.2		 3twpB-2hz7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 GLY A 181
ARG A 214
GLU A 169
ARG A 172
 None
 1.19A 4bqfA-2hz7A:
undetectable		 4bqfA-2hz7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASN A 194
LEU A 213
ARG A 214
GLY A 158
 None
 0.82A 4cp3A-2hz7A:
undetectable
4cp3B-2hz7A:
undetectable		 4cp3A-2hz7A:
10.30
4cp3B-2hz7A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 ASP A 375
ARG A 428
THR A 343
 None
 0.83A 4i13A-2hz7A:
undetectable		 4i13A-2hz7A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 5 ASN A 236
GLY A 204
ASP A 142
ASP A 244
 None
 1.09A 4n48B-2hz7A:
undetectable		 4n48B-2hz7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 4 ASN A 236
GLY A 204
ASP A 142
ASP A 244
 None
 1.10A 4n49A-2hz7A:
undetectable		 4n49A-2hz7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 9 GLY A 465
ALA A 478
ASP A 479
VAL A 392
ILE A 475
 None
 1.19A 4njtD-2hz7A:
undetectable		 4njtD-2hz7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 ASP A 375
ARG A 428
THR A 343
 None
 0.81A 4p3rA-2hz7A:
undetectable		 4p3rA-2hz7A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 451
ASP A 450
PRO A 455
ILE A 476
 None
 1.01A 4pcuA-2hz7A:
3.2		 4pcuA-2hz7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 8 LEU A 444
VAL A 468
LEU A 462
ILE A 476
PHE A 481
 None
 1.47A 4r38D-2hz7A:
undetectable		 4r38D-2hz7A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 THR A 495
ALA A 494
ASP A 479
LEU A 444
PRO A 464
 None
 1.25A 4xi3A-2hz7A:
undetectable		 4xi3A-2hz7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  48
PHE A  86
THR A  94
GLY A 355
 None
 0.80A 5v0vA-2hz7A:
undetectable		 5v0vA-2hz7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 ASP A  59
LEU A 104
ALA A 140
ILE A 262
ALA A 261
 None
 1.10A 5vc0A-2hz7A:
undetectable		 5vc0A-2hz7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 5 ARG A  96
PHE A  72
PHE A  92
LEU A  89
 None
 1.35A 5veuH-2hz7A:
undetectable		 5veuH-2hz7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 TYR A 143
ASP A 145
ASP A 142
 None
 0.82A 5x6yA-2hz7A:
undetectable		 5x6yA-2hz7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 ILE A 308
ARG A 525
THR A 571
LEU A 570
 None
 1.01A 5z86N-2hz7A:
undetectable
5z86W-2hz7A:
undetectable		 5z86N-2hz7A:
19.81
5z86W-2hz7A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hz7 GLUTAMINYL-TRNA
SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 ILE A 308
ARG A 525
THR A 571
LEU A 570
 None
 1.03A 5zcoN-2hz7A:
undetectable
5zcoW-2hz7A:
undetectable		 5zcoN-2hz7A:
19.81
5zcoW-2hz7A:
5.21