SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2hzf GLUTAREDOXIN-1
(Ectromelia
virus) 		5 / 12 PHE A  75
THR A  65
VAL A  15
LEU A  33
PHE A  18
 None
 1.09A 2jn3A-2hzfA:
undetectable		 2jn3A-2hzfA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2hzf GLUTAREDOXIN-1
(Ectromelia
virus) 		4 / 7 ILE A 102
LEU A  99
LEU A  33
VAL A  19
 None
 1.01A 3r9vA-2hzfA:
undetectable
3r9vB-2hzfA:
undetectable		 3r9vA-2hzfA:
18.02
3r9vB-2hzfA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2hzf GLUTAREDOXIN-1
(Ectromelia
virus) 		5 / 12 PHE A  75
ILE A  98
ILE A  89
LEU A  86
VAL A  15
 None
 0.98A 5uvmB-2hzfA:
undetectable		 5uvmB-2hzfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2hzf GLUTAREDOXIN-1
(Ectromelia
virus) 		5 / 12 ILE A  80
ASP A  85
LEU A  95
ALA A  94
LEU A  99
 None
 0.92A 6bq4A-2hzfA:
undetectable		 6bq4A-2hzfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2hzf GLUTAREDOXIN-1
(Ectromelia
virus) 		4 / 8 LEU A  33
VAL A 104
LEU A  99
ILE A 102
 None
 0.67A 6cb4A-2hzfA:
undetectable		 6cb4A-2hzfA:
13.23