SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 218
LEU A 215
ILE A 171
HIS A 238
ILE A 250
 None
 0.94A 1tw4A-2hzgA:
undetectable		 1tw4A-2hzgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 218
LEU A 215
ILE A 171
HIS A 238
ILE A 250
 None
 0.92A 1tw4B-2hzgA:
undetectable		 1tw4B-2hzgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.96A 2f80A-2hzgA:
undetectable		 2f80A-2hzgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.98A 2f80B-2hzgA:
undetectable		 2f80B-2hzgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.95A 2f8gA-2hzgA:
undetectable		 2f8gA-2hzgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 1.00A 2hs2A-2hzgA:
undetectable		 2hs2A-2hzgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 1.01A 2hs2B-2hzgA:
undetectable		 2hs2B-2hzgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 8 ASP A   9
ILE A 106
GLY A  40
ILE A  39
LEU A  72
 None
 1.46A 2o4nB-2hzgA:
undetectable		 2o4nB-2hzgA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.95A 2pymA-2hzgA:
undetectable		 2pymA-2hzgA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 215
LEU A 218
ASP A 219
ARG A 247
 None
 1.15A 2rlfB-2hzgA:
undetectable
2rlfC-2hzgA:
undetectable		 2rlfB-2hzgA:
6.48
2rlfC-2hzgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 282
GLY A 279
ALA A 314
LEU A 284
VAL A  89
 None
 1.11A 2zulA-2hzgA:
undetectable		 2zulA-2hzgA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  42
SER A 308
THR A 307
LEU A 362
ALA A 314
 None
 1.25A 3d91A-2hzgA:
undetectable		 3d91A-2hzgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 282
GLY A 279
ALA A 314
LEU A 284
VAL A  89
 None
 1.09A 3dmhA-2hzgA:
2.6		 3dmhA-2hzgA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.98A 3el1A-2hzgA:
undetectable		 3el1A-2hzgA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 9 ALA A  28
ASP A  27
LEU A  10
VAL A 366
ILE A 341
 None
 1.07A 3em4B-2hzgA:
undetectable		 3em4B-2hzgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		4 / 8 ALA A 256
ILE A 281
ASN A 258
PRO A 286
 None
 0.95A 3fxrA-2hzgA:
undetectable		 3fxrA-2hzgA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.97A 3oxxB-2hzgA:
undetectable		 3oxxB-2hzgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.93A 3oxxC-2hzgA:
undetectable		 3oxxC-2hzgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.97A 3oxxD-2hzgA:
undetectable		 3oxxD-2hzgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		4 / 7 PRO A 318
GLY A 285
ALA A 287
ASP A 277
 None
 0.86A 3ur0B-2hzgA:
undetectable		 3ur0B-2hzgA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.94A 4fp9A-2hzgA:
undetectable		 4fp9A-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.95A 4fp9C-2hzgA:
undetectable		 4fp9C-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.94A 4fp9D-2hzgA:
undetectable		 4fp9D-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.86A 4fzvA-2hzgA:
undetectable		 4fzvA-2hzgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.88A 4hlaA-2hzgA:
undetectable		 4hlaA-2hzgA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 310
ALA A  28
ASP A  27
VAL A 366
ILE A 341
 None
 0.87A 4hlaB-2hzgA:
undetectable		 4hlaB-2hzgA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 353
ALA A 138
LEU A 316
ARG A 355
GLY A 321
 None
 1.34A 4l9qA-2hzgA:
undetectable		 4l9qA-2hzgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		5 / 9 ASP A 277
VAL A 290
ALA A 291
GLY A 282
SER A 315
 None
 1.14A 4mm5A-2hzgA:
undetectable		 4mm5A-2hzgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 277
GLU A 227
SER A  51
 None
NA  A1101 (-3.2A)
None
 0.82A 5bw4B-2hzgA:
2.3		 5bw4B-2hzgA:
23.26