SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		3 / 3 PHE A 249
LEU A 265
MET A  57
 None
 0.87A 1mx1D-2hzkA:
undetectable		 1mx1D-2hzkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 8 TYR A 219
ASP A  45
TYR A 280
HIS A  95
 None
 1.43A 2ha2B-2hzkA:
undetectable		 2ha2B-2hzkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 7 PHE A 181
PHE A 327
ILE A 334
GLY A  98
 None
 0.91A 2v0mC-2hzkA:
undetectable		 2v0mC-2hzkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 7 PHE A 181
SER A 117
ILE A 334
GLY A  98
 None
 0.91A 2v0mC-2hzkA:
undetectable		 2v0mC-2hzkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 7 LEU A 265
LEU A 257
PHE A  66
LEU A  54
 None
 0.91A 2vq5B-2hzkA:
undetectable		 2vq5B-2hzkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 7 VAL A 216
ASN A 152
GLY A 151
VAL A  97
 None
 0.96A 2y05A-2hzkA:
undetectable
2y05B-2hzkA:
undetectable		 2y05A-2hzkA:
23.83
2y05B-2hzkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 8 LEU A 110
ILE A 334
PHE A 337
GLY A 122
 None
 0.95A 3b9lA-2hzkA:
undetectable		 3b9lA-2hzkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 8 MET A 320
PHE A 327
TYR A 317
ALA A 109
 None
 1.01A 3l4dD-2hzkA:
undetectable		 3l4dD-2hzkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 6 GLU A 240
THR A  96
ALA A 113
ALA A 112
 GOL  A 801 (-3.8A)
None
None
None
 1.03A 3ns1C-2hzkA:
undetectable		 3ns1C-2hzkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 183
GLU A 187
GLY A 180
PRO A 193
 None
 0.99A 3onnA-2hzkA:
undetectable		 3onnA-2hzkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		5 / 11 ALA A 147
GLY A  98
VAL A  97
VAL A  86
ILE A 145
 None
 1.24A 3oxxB-2hzkA:
undetectable		 3oxxB-2hzkA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 8 TRP A 160
GLU A 222
GLN A 294
SER A 290
 None
 0.95A 4f93B-2hzkA:
undetectable		 4f93B-2hzkA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 150
VAL A 245
PRO A 149
TYR A 128
 None
 1.12A 4grkA-2hzkA:
4.9		 4grkA-2hzkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 151
VAL A 245
PRO A 149
TYR A 128
 None
 1.15A 4grkA-2hzkA:
4.9		 4grkA-2hzkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 112
ALA A 109
THR A 153
GLY A 242
GLY A 241
 None
 0.90A 4qvpK-2hzkA:
undetectable
4qvpL-2hzkA:
undetectable		 4qvpK-2hzkA:
23.17
4qvpL-2hzkA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 112
ALA A 109
THR A 153
GLY A 242
GLY A 241
 None
 0.91A 4qvpY-2hzkA:
undetectable
4qvpZ-2hzkA:
undetectable		 4qvpY-2hzkA:
23.17
4qvpZ-2hzkA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 5 GLU A 240
ILE A  47
THR A 153
TYR A 100
 GOL  A 801 (-3.8A)
GOL  A 801 ( 4.9A)
None
None
 1.34A 4qwpB-2hzkA:
0.0		 4qwpB-2hzkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 151
PRO A 149
ASP A 273
ALA A 274
TYR A 280
 None
 1.47A 5c8tB-2hzkA:
undetectable		 5c8tB-2hzkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		3 / 3 VAL A 168
GLN A 307
CYH A 309
 None
 0.90A 5icxC-2hzkA:
undetectable
5icxF-2hzkA:
undetectable		 5icxC-2hzkA:
19.73
5icxF-2hzkA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 242
SER A 119
GLY A 122
ASN A 152
 None
 0.79A 5k4pA-2hzkA:
undetectable		 5k4pA-2hzkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 7 PHE A 116
GLY A 158
TYR A 235
TYR A 234
 None
 0.98A 5uxdA-2hzkA:
undetectable		 5uxdA-2hzkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 342
VAL A 316
PHE A 337
GLY A 122
 None
 0.92A 6hd4A-2hzkA:
undetectable		 6hd4A-2hzkA:
12.50