SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae) 		3 / 3 THR B 271
LEU B 275
LEU B 282
 None
 0.65A 1mz9C-2hzsB:
undetectable		 1mz9C-2hzsB:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 297
GLU B 212
TYR B 215
 None
 0.77A 1wsvA-2hzsB:
2.2		 1wsvA-2hzsB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 101
THR A  98
VAL A  92
SER A  97
ALA A  84
 None
 1.16A 2v41A-2hzsA:
undetectable
2v41B-2hzsA:
undetectable		 2v41A-2hzsA:
21.65
2v41B-2hzsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 101
THR A  98
VAL A  92
SER A  97
ALA A  84
 None
 1.12A 2v41A-2hzsA:
undetectable
2v41B-2hzsA:
undetectable		 2v41A-2hzsA:
21.65
2v41B-2hzsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 MET B 296
PHE I 206
ILE B 185
ASN B 258
 None
 1.04A 2zseA-2hzsB:
undetectable		 2zseA-2hzsB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8
(Saccharomyces
cerevisiae) 		4 / 6 VAL I 198
SER B   6
LEU B  23
LEU B 252
 None
 0.91A 3kk6A-2hzsI:
undetectable		 3kk6A-2hzsI:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8
(Saccharomyces
cerevisiae) 		4 / 6 VAL I 198
SER B   6
LEU B  23
LEU B 252
 None
 0.90A 3kk6B-2hzsI:
undetectable		 3kk6B-2hzsI:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 PRO I 195
SER B  10
ASN I 197
 None
 0.90A 3lslG-2hzsI:
undetectable		 3lslG-2hzsI:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 137
LEU A 155
LEU A 139
GLY A 169
LEU A  24
 None
 1.07A 3nt1A-2hzsA:
undetectable		 3nt1A-2hzsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 137
LEU A 155
LEU A 139
GLY A 169
LEU A  24
 None
 1.08A 3nt1B-2hzsA:
undetectable		 3nt1B-2hzsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 123
LEU A 121
SER A  59
THR A  61
 None
 0.84A 4d7bA-2hzsA:
undetectable		 4d7bA-2hzsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  95
ALA A  84
VAL A  92
PHE B 223
ILE B 229
 None
 1.31A 4j4vA-2hzsA:
undetectable		 4j4vA-2hzsA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae) 		4 / 8 ILE B  64
LYS B  65
ILE B 168
ALA B 186
 None
 0.94A 4ou1A-2hzsB:
undetectable		 4ou1A-2hzsB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		4 / 5 THR A  61
THR A  69
ASP A 105
TYR A  42
 None
 1.49A 4qwpB-2hzsA:
undetectable		 4qwpB-2hzsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 139
LEU A 151
ILE A 153
GLU A 164
ILE A   7
 None
 0.95A 4y0rA-2hzsA:
1.8		 4y0rA-2hzsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ILE A 115
GLY B 206
ILE A  46
LEU B 207
 None
 0.88A 5dzki-2hzsA:
undetectable
5dzkj-2hzsA:
undetectable
5dzkx-2hzsA:
undetectable		 5dzki-2hzsA:
22.61
5dzkj-2hzsA:
22.61
5dzkx-2hzsA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ILE A 115
GLY B 206
ILE A  46
LEU B 207
 None
 0.89A 5dzkd-2hzsA:
undetectable
5dzkk-2hzsA:
undetectable
5dzky-2hzsA:
undetectable		 5dzkd-2hzsA:
24.80
5dzkk-2hzsA:
22.61
5dzky-2hzsA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 ILE A 115
GLY B 206
ILE A  46
LEU B 207
 None
 0.84A 5dzkl-2hzsA:
undetectable
5dzkz-2hzsA:
undetectable		 5dzkl-2hzsA:
22.61
5dzkz-2hzsA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY B 206
ASN B 205
SER B 165
ILE B 190
MET A  78
 None
 1.23A 5ih0A-2hzsB:
undetectable		 5ih0A-2hzsB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 111
LEU B 207
ILE A 104
 None
 0.67A 5kc0A-2hzsA:
undetectable		 5kc0A-2hzsA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 207
LEU A 208
VAL A 205
LEU A 142
ILE A  37
 None
 1.01A 5v02B-2hzsA:
undetectable
5v02R-2hzsA:
undetectable		 5v02B-2hzsA:
19.62
5v02R-2hzsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 123
LEU A 121
ARG A  40
 None
 0.85A 5yw0A-2hzsA:
undetectable		 5yw0A-2hzsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 124
ASP A  38
ILE A  60
 None
 0.59A 6dgxB-2hzsA:
undetectable		 6dgxB-2hzsA:
19.27