SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.14A 1c8lA-2i00A:
undetectable		 1c8lA-2i00A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A  23
LEU A  57
ILE A  77
ALA A  76
TYR A 100
 None
 0.86A 1cbsA-2i00A:
undetectable		 1cbsA-2i00A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.12A 1gfzA-2i00A:
undetectable		 1gfzA-2i00A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.10A 1l5qA-2i00A:
undetectable		 1l5qA-2i00A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.09A 1l5qB-2i00A:
undetectable		 1l5qB-2i00A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.10A 1l7xA-2i00A:
undetectable		 1l7xA-2i00A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.13A 1l7xB-2i00A:
undetectable		 1l7xB-2i00A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 SER A 147
ILE A  84
ILE A 127
ILE A 299
PHE A 305
 None
 0.90A 1qhsA-2i00A:
undetectable		 1qhsA-2i00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 PHE A 311
LEU A 336
LEU A 391
LEU A 365
 None
 0.92A 2bfpC-2i00A:
undetectable		 2bfpC-2i00A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A  43
VAL A  33
LEU A  27
ILE A  50
SER A  52
 None
 1.42A 2fj1A-2i00A:
undetectable		 2fj1A-2i00A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A  23
LEU A  57
ILE A  77
ALA A  76
TYR A 100
 None
 0.84A 2fr3A-2i00A:
undetectable		 2fr3A-2i00A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 ASP A 404
TRP A 205
TYR A 401
TYR A 183
 None
 1.43A 2ha2B-2i00A:
undetectable		 2ha2B-2i00A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 7 PHE A 309
PRO A 372
LEU A 365
PHE A 320
 None
 1.00A 2vcvA-2i00A:
undetectable		 2vcvA-2i00A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 7 PHE A 309
PRO A 372
LEU A 365
PHE A 320
 None
 0.87A 2vcvG-2i00A:
undetectable		 2vcvG-2i00A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 7 PHE A 309
PRO A 372
LEU A 365
PHE A 320
 None
 0.96A 2vcvL-2i00A:
undetectable		 2vcvL-2i00A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 ARG A 298
MET A 120
TYR A  89
ILE A  84
HIS A 191
 None
 1.48A 2vufA-2i00A:
undetectable		 2vufA-2i00A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 5 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.09A 3bcrA-2i00A:
undetectable		 3bcrA-2i00A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.08A 3dd1A-2i00A:
undetectable		 3dd1A-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.12A 3dd1B-2i00A:
undetectable		 3dd1B-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.08A 3ddsA-2i00A:
undetectable		 3ddsA-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.08A 3ddsB-2i00A:
undetectable		 3ddsB-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.07A 3ddwA-2i00A:
undetectable		 3ddwA-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASN A 247
ALA A 250
GLY A 227
TYR A 245
 None
 1.10A 3ddwB-2i00A:
undetectable		 3ddwB-2i00A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 GLY A 220
GLU A 249
GLY A 167
ASN A 222
 None
 0.92A 3e9rA-2i00A:
undetectable		 3e9rA-2i00A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 GLY A 220
GLU A 249
GLY A 167
ASN A 222
 None
 0.96A 3e9rC-2i00A:
undetectable		 3e9rC-2i00A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 HIS A  85
ASN A 368
ARG A 371
GLU A 312
 None
 1.34A 3galA-2i00A:
undetectable		 3galA-2i00A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 5 LEU A  59
LYS A  53
GLN A  54
GLU A  58
 None
 1.08A 3h5gA-2i00A:
undetectable
3h5gB-2i00A:
undetectable		 3h5gA-2i00A:
7.21
3h5gB-2i00A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 GLU A 399
HIS A 191
ASN A 368
MET A 367
 None
 1.21A 3kp6A-2i00A:
undetectable
3kp6B-2i00A:
undetectable		 3kp6A-2i00A:
17.35
3kp6B-2i00A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		3 / 3 PHE A 207
LYS A  53
SER A  52
 None
 0.96A 3tyeB-2i00A:
undetectable		 3tyeB-2i00A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		3 / 3 LYS A 141
PRO A 325
LYS A 110
 None
 1.28A 4dr5L-2i00A:
undetectable		 4dr5L-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		3 / 3 LYS A 141
PRO A 325
LYS A 110
 None
 1.38A 4dr6L-2i00A:
0.0		 4dr6L-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		3 / 3 LYS A 141
PRO A 325
LYS A 110
 None
 1.32A 4duzL-2i00A:
undetectable		 4duzL-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		3 / 3 LYS A 141
PRO A 325
LYS A 110
 None
 1.38A 4dv7L-2i00A:
undetectable		 4dv7L-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 11 ILE A 127
ILE A 359
LEU A 117
ALA A 297
VAL A 366
 None
 0.96A 4h1nA-2i00A:
undetectable		 4h1nA-2i00A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 7 GLY A  93
ILE A  75
GLN A 114
TYR A 138
 None
 1.05A 5vlmC-2i00A:
undetectable		 5vlmC-2i00A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A 320
VAL A 322
PHE A 395
VAL A 302
PHE A 305
 None
 1.34A 6ap6B-2i00A:
undetectable		 6ap6B-2i00A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 9 ALA A 279
ILE A 287
GLY A 270
PHE A 152
SER A 290
 None
 1.36A 6awoA-2i00A:
undetectable		 6awoA-2i00A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A  64
TRP A  65
ILE A  75
LEU A  57
GLY A  96
 None
 1.39A 6bp4B-2i00A:
undetectable		 6bp4B-2i00A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2i00 ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 ASP A 404
TYR A 401
GLU A 242
GLU A 208
 None
 1.42A 6mn5C-2i00A:
undetectable		 6mn5C-2i00A:
12.16