SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 187
VAL A 186
ILE A 300
ILE A 299
GLN A 189
 None
 1.42A 1gx9A-2i05A:
undetectable		 1gx9A-2i05A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		5 / 9 LYS A  59
ASN A  64
GLN A  67
ALA A  36
VAL A  38
 None
 1.40A 1n3zA-2i05A:
undetectable		 1n3zA-2i05A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 GLN A  19
HIS A 116
LEU A 159
LEU A  71
HIS A 113
 None
 1.45A 3adxA-2i05A:
0.0		 3adxA-2i05A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 116
HIS A 113
ILE A 117
 None
 0.71A 3u52A-2i05A:
undetectable
3u52C-2i05A:
undetectable		 3u52A-2i05A:
21.35
3u52C-2i05A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		5 / 11 ASP A 281
PRO A 238
VAL A 236
ALA A 173
GLY A 171
 None
 1.08A 4mmaA-2i05A:
undetectable		 4mmaA-2i05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 LEU A  28
ASN A 264
LEU A  34
 None
 0.66A 6exiA-2i05A:
undetectable		 6exiA-2i05A:
17.72