SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 ALA A  71
VAL A  91
TRP A  90
 None
 0.96A 1grmA-2i0kA:
undetectable		 1grmA-2i0kA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 ALA A  71
VAL A  91
TRP A  90
 None
 0.96A 1grmB-2i0kA:
undetectable		 1grmB-2i0kA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.43A 1k2sA-2i0kA:
undetectable
1k2sB-2i0kA:
undetectable		 1k2sA-2i0kA:
21.61
1k2sB-2i0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 8 GLU A 475
SER A 367
ASP A 368
GLU A 432
 GOL  A 706 ( 3.1A)
None
None
CAC  A 705 (-3.1A)
 1.16A 1knyA-2i0kA:
undetectable
1knyB-2i0kA:
undetectable		 1knyA-2i0kA:
17.26
1knyB-2i0kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.47A 1lzxA-2i0kA:
undetectable
1lzxB-2i0kA:
undetectable		 1lzxA-2i0kA:
21.61
1lzxB-2i0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.38A 1lzxA-2i0kA:
undetectable
1lzxB-2i0kA:
undetectable		 1lzxA-2i0kA:
21.61
1lzxB-2i0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.48A 1lzzA-2i0kA:
undetectable
1lzzB-2i0kA:
undetectable		 1lzzA-2i0kA:
21.61
1lzzB-2i0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.46A 1mmwA-2i0kA:
undetectable
1mmwB-2i0kA:
undetectable		 1mmwA-2i0kA:
21.61
1mmwB-2i0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.44A 1om4A-2i0kA:
undetectable
1om4B-2i0kA:
undetectable		 1om4A-2i0kA:
20.61
1om4B-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.31A 1p6hA-2i0kA:
undetectable
1p6hB-2i0kA:
undetectable		 1p6hA-2i0kA:
20.65
1p6hB-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.49A 1p6iA-2i0kA:
undetectable
1p6iB-2i0kA:
undetectable		 1p6iA-2i0kA:
20.65
1p6iB-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.46A 1p6jA-2i0kA:
undetectable
1p6jB-2i0kA:
undetectable		 1p6jA-2i0kA:
20.65
1p6jB-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 8 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.34A 1rs6A-2i0kA:
undetectable
1rs6B-2i0kA:
2.0		 1rs6A-2i0kA:
20.65
1rs6B-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.47A 1rs7A-2i0kA:
undetectable
1rs7B-2i0kA:
undetectable		 1rs7A-2i0kA:
20.65
1rs7B-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 LEU A 222
LEU A 225
VAL A 157
LEU A 175
ILE A 168
 None
 1.08A 1s9pD-2i0kA:
undetectable		 1s9pD-2i0kA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 9 GLY A 195
ALA A 196
SER A 192
LEU A 191
TRP A 182
 FAD  A 700 (-3.3A)
None
FAD  A 700 (-2.6A)
FAD  A 700 (-4.2A)
None
 1.09A 1y7iA-2i0kA:
undetectable		 1y7iA-2i0kA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 6 ARG A 260
ASP A 609
THR A 604
ASP A 598
 None
 1.20A 2j2pE-2i0kA:
undetectable
2j2pF-2i0kA:
undetectable		 2j2pE-2i0kA:
18.80
2j2pF-2i0kA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 607
LEU A 611
LEU A 612
PRO A 116
 None
None
None
FAD  A 700 (-4.2A)
 0.96A 2jn3A-2i0kA:
undetectable		 2jn3A-2i0kA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 608
VAL A 569
THR A 570
ARG A 591
 None
 1.06A 2kotA-2i0kA:
0.0		 2kotA-2i0kA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.32A 2nsiA-2i0kA:
undetectable
2nsiB-2i0kA:
undetectable		 2nsiA-2i0kA:
21.40
2nsiB-2i0kA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 6 GLY A 433
GLY A 472
PHE A 455
PHE A 451
 None
 0.96A 2qx6A-2i0kA:
undetectable
2qx6B-2i0kA:
undetectable		 2qx6A-2i0kA:
18.32
2qx6B-2i0kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 LEU A  86
TYR A  77
GLN A  78
 None
 0.41A 2wekA-2i0kA:
undetectable		 2wekA-2i0kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.46A 2yldA-2i0kA:
undetectable		 2yldA-2i0kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.45A 2ylgA-2i0kA:
undetectable		 2ylgA-2i0kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 499
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.48A 2ylgA-2i0kA:
undetectable		 2ylgA-2i0kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 GLN A 276
SER A 416
LEU A 175
LEU A 222
HIS A 217
 None
 1.49A 3adxA-2i0kA:
undetectable		 3adxA-2i0kA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.44A 3b3nA-2i0kA:
undetectable
3b3nB-2i0kA:
undetectable		 3b3nA-2i0kA:
20.61
3b3nB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 ILE A 513
PHE A 300
HIS A 202
 None
None
FAD  A 700 (-3.9A)
 0.72A 3h0aA-2i0kA:
undetectable		 3h0aA-2i0kA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 3hsoA-2i0kA:
undetectable
3hsoB-2i0kA:
undetectable		 3hsoA-2i0kA:
20.61
3hsoB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.37A 3hsoA-2i0kA:
undetectable
3hsoB-2i0kA:
undetectable		 3hsoA-2i0kA:
20.61
3hsoB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.37A 3hspA-2i0kA:
undetectable
3hspB-2i0kA:
undetectable		 3hspA-2i0kA:
20.61
3hspB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.33A 3hspA-2i0kA:
undetectable
3hspB-2i0kA:
undetectable		 3hspA-2i0kA:
20.61
3hspB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.46A 3jt8A-2i0kA:
undetectable
3jt8B-2i0kA:
undetectable		 3jt8A-2i0kA:
20.61
3jt8B-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.47A 3n2rA-2i0kA:
undetectable
3n2rB-2i0kA:
undetectable		 3n2rA-2i0kA:
20.61
3n2rB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.45A 3n2rA-2i0kA:
undetectable
3n2rB-2i0kA:
undetectable		 3n2rA-2i0kA:
20.61
3n2rB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 THR A 500
GLY A 480
GLY A 203
HIS A 202
ASP A 510
 None
None
None
FAD  A 700 (-3.9A)
None
 1.25A 3tkaA-2i0kA:
undetectable		 3tkaA-2i0kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 9 ARG A 246
ALA A 231
GLY A 194
ILE A 193
LEU A 255
 None
None
FAD  A 700 ( 4.0A)
None
None
 1.14A 3u7sB-2i0kA:
undetectable		 3u7sB-2i0kA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.46A 3zwiA-2i0kA:
undetectable		 3zwiA-2i0kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.45A 4caqA-2i0kA:
undetectable
4caqB-2i0kA:
undetectable		 4caqA-2i0kA:
20.61
4caqB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 4 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.45A 4cipA-2i0kA:
undetectable		 4cipA-2i0kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.47A 4d31A-2i0kA:
undetectable
4d31B-2i0kA:
undetectable		 4d31A-2i0kA:
20.61
4d31B-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.40A 4eilA-2i0kA:
undetectable		 4eilA-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.41A 4eilC-2i0kA:
undetectable		 4eilC-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.39A 4eilE-2i0kA:
undetectable		 4eilE-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 ARG A 591
TYR A 563
ASN A 605
 None
 0.86A 4ffwB-2i0kA:
undetectable		 4ffwB-2i0kA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 9 GLY A 435
GLY A 434
MET A 533
GLU A 551
ILE A 476
 None
None
None
CAC  A 705 ( 4.8A)
None
 1.20A 4fgjA-2i0kA:
undetectable
4fgjB-2i0kA:
undetectable		 4fgjA-2i0kA:
20.17
4fgjB-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
CAC  A 705 ( 4.8A)
 1.11A 4fgkB-2i0kA:
undetectable		 4fgkB-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
CAC  A 705 ( 4.8A)
 1.11A 4fglC-2i0kA:
undetectable		 4fglC-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.45A 4fvwA-2i0kA:
undetectable
4fvwB-2i0kA:
undetectable		 4fvwA-2i0kA:
20.61
4fvwB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.49A 4fvyA-2i0kA:
undetectable
4fvyB-2i0kA:
undetectable		 4fvyA-2i0kA:
20.61
4fvyB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.45A 4fvyA-2i0kA:
undetectable
4fvyB-2i0kA:
undetectable		 4fvyA-2i0kA:
20.61
4fvyB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 6 ALA A 442
ASN A 443
VAL A 447
ASP A 545
 None
GOL  A 708 (-3.3A)
GOL  A 708 (-3.9A)
MN  A 702 ( 2.6A)
 0.91A 4g24A-2i0kA:
undetectable		 4g24A-2i0kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.44A 4gqeA-2i0kA:
undetectable
4gqeB-2i0kA:
undetectable		 4gqeA-2i0kA:
20.61
4gqeB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 4k5eA-2i0kA:
undetectable
4k5eB-2i0kA:
undetectable		 4k5eA-2i0kA:
20.61
4k5eB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.38A 4k5gA-2i0kA:
undetectable
4k5gB-2i0kA:
undetectable		 4k5gA-2i0kA:
20.61
4k5gB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.48A 4kcmA-2i0kA:
undetectable
4kcmB-2i0kA:
undetectable		 4kcmA-2i0kA:
20.61
4kcmB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.46A 4kcoA-2i0kA:
undetectable
4kcoB-2i0kA:
undetectable		 4kcoA-2i0kA:
20.61
4kcoB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.43A 4kyaA-2i0kA:
undetectable		 4kyaA-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.45A 4kyaB-2i0kA:
undetectable		 4kyaB-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.42A 4kyaC-2i0kA:
undetectable		 4kyaC-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.43A 4kyaE-2i0kA:
undetectable		 4kyaE-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 11 VAL A 232
ALA A 240
SER A 265
LEU A 146
VAL A 100
 None
 1.43A 4kyaG-2i0kA:
undetectable		 4kyaG-2i0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.46A 4luxA-2i0kA:
undetectable
4luxB-2i0kA:
undetectable		 4luxA-2i0kA:
20.61
4luxB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 8 GLY A 148
GLY A 165
ILE A 193
LEU A 263
 None
None
None
FAD  A 700 (-4.0A)
 0.76A 4mwzB-2i0kA:
undetectable		 4mwzB-2i0kA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 HIS A 217
GLN A 420
LEU A 222
LEU A 175
ASN A 273
 None
 1.38A 4qdcA-2i0kA:
0.0		 4qdcA-2i0kA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 THR A 500
GLY A 203
GLY A 480
LEU A 185
ALA A 187
 None
None
None
None
FAD  A 700 (-3.5A)
 0.91A 4uciA-2i0kA:
undetectable		 4uciA-2i0kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 THR A 500
GLY A 203
GLY A 480
LEU A 185
ALA A 187
 None
None
None
None
FAD  A 700 (-3.5A)
 0.93A 4uciB-2i0kA:
undetectable		 4uciB-2i0kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 THR A 500
GLY A 203
GLY A 480
LEU A 185
ALA A 187
 None
None
None
None
FAD  A 700 (-3.5A)
 0.91A 4uckA-2i0kA:
undetectable		 4uckA-2i0kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.43A 4uh5A-2i0kA:
undetectable
4uh5B-2i0kA:
undetectable		 4uh5A-2i0kA:
20.48
4uh5B-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.42A 4upoA-2i0kA:
undetectable
4upoB-2i0kA:
undetectable		 4upoA-2i0kA:
20.61
4upoB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 PHE A 421
LEU A 185
GLY A 195
LEU A 197
VAL A 266
 None
None
FAD  A 700 (-3.3A)
None
None
 1.21A 4wnwA-2i0kA:
undetectable		 4wnwA-2i0kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 GLY A 181
SER A 416
ASN A 273
HIS A 217
 None
 1.08A 4ws0A-2i0kA:
undetectable		 4ws0A-2i0kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 ARG A 591
ASP A 588
TRP A 587
 None
 1.01A 4xdqA-2i0kA:
undetectable		 4xdqA-2i0kA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.38A 5adgA-2i0kA:
undetectable
5adgB-2i0kA:
undetectable		 5adgA-2i0kA:
20.48
5adgB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.43A 5agnA-2i0kA:
undetectable
5agnB-2i0kA:
undetectable		 5agnA-2i0kA:
20.61
5agnB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 PRO A 495
LEU A 255
GLY A 220
MET A 268
LEU A 197
 None
 1.47A 5emlA-2i0kA:
undetectable		 5emlA-2i0kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.41A 5fvtA-2i0kA:
undetectable
5fvtB-2i0kA:
undetectable		 5fvtA-2i0kA:
20.61
5fvtB-2i0kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.41A 5fvuA-2i0kA:
undetectable
5fvuB-2i0kA:
2.0		 5fvuA-2i0kA:
20.48
5fvuB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.40A 5fvvA-2i0kA:
undetectable
5fvvB-2i0kA:
undetectable		 5fvvA-2i0kA:
20.48
5fvvB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 5fvwA-2i0kA:
undetectable
5fvwB-2i0kA:
undetectable		 5fvwA-2i0kA:
20.48
5fvwB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ASP A 141
HIS A 145
GLY A 165
ALA A 166
 None
 0.95A 5hwaA-2i0kA:
undetectable		 5hwaA-2i0kA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.43A 5jliA-2i0kA:
undetectable		 5jliA-2i0kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 499
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.47A 5jliA-2i0kA:
undetectable		 5jliA-2i0kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 4 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.47A 5jslA-2i0kA:
undetectable		 5jslA-2i0kA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 436
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.45A 5jt4A-2i0kA:
undetectable		 5jt4A-2i0kA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 5 ALA A 499
GLY A 480
CYH A 479
HIS A 202
 None
None
None
FAD  A 700 (-3.9A)
 1.50A 5jt4A-2i0kA:
undetectable		 5jt4A-2i0kA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 ILE A 476
GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
None
CAC  A 705 ( 4.8A)
 1.39A 5lbtA-2i0kA:
undetectable
5lbtB-2i0kA:
undetectable		 5lbtA-2i0kA:
18.48
5lbtB-2i0kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 12 LEU A 289
SER A 307
ALA A 204
ALA A 310
GLY A 309
 None
 1.16A 5tzoB-2i0kA:
undetectable		 5tzoB-2i0kA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 5uo1A-2i0kA:
undetectable
5uo1B-2i0kA:
undetectable		 5uo1A-2i0kA:
20.48
5uo1B-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 ILE A 171
LEU A 197
THR A 218
THR A 230
 None
 1.03A 5vc0A-2i0kA:
undetectable		 5vc0A-2i0kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.40A 5vuwA-2i0kA:
undetectable
5vuwB-2i0kA:
undetectable		 5vuwA-2i0kA:
20.48
5vuwB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.39A 5vuxA-2i0kA:
undetectable
5vuxB-2i0kA:
undetectable		 5vuxA-2i0kA:
20.48
5vuxB-2i0kA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 LEU A 612
TYR A 594
ILE A 597
LEU A 197
ALA A 198
 None
None
None
None
FAD  A 700 (-3.3A)
 1.22A 5y7pB-2i0kA:
undetectable		 5y7pB-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 LEU A 612
TYR A 594
ILE A 597
LEU A 254
LEU A 197
 None
 1.04A 5y7pG-2i0kA:
undetectable		 5y7pG-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 TYR A 594
ILE A 597
LEU A 254
LEU A 197
ALA A 198
 None
None
None
None
FAD  A 700 (-3.3A)
 1.17A 5y7pG-2i0kA:
undetectable		 5y7pG-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		5 / 10 LEU A 612
TYR A 594
ILE A 597
LEU A 197
ALA A 198
 None
None
None
None
FAD  A 700 (-3.3A)
 1.25A 5y7pH-2i0kA:
undetectable		 5y7pH-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 6aurA-2i0kA:
undetectable
6aurB-2i0kA:
undetectable		 6aurA-2i0kA:
10.69
6aurB-2i0kA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.35A 6aurA-2i0kA:
undetectable
6aurB-2i0kA:
undetectable		 6aurA-2i0kA:
10.69
6aurB-2i0kA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 6autA-2i0kA:
undetectable
6autB-2i0kA:
undetectable		 6autA-2i0kA:
10.69
6autB-2i0kA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.44A 6auvA-2i0kA:
undetectable
6auvB-2i0kA:
undetectable		 6auvA-2i0kA:
10.69
6auvB-2i0kA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.43A 6av0A-2i0kA:
undetectable
6av0B-2i0kA:
2.0		 6av0A-2i0kA:
10.30
6av0B-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.36A 6av1A-2i0kA:
undetectable
6av1B-2i0kA:
undetectable		 6av1A-2i0kA:
10.30
6av1B-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.41A 6av3A-2i0kA:
undetectable
6av3B-2i0kA:
2.0		 6av3A-2i0kA:
10.30
6av3B-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.41A 6av4A-2i0kA:
undetectable
6av4B-2i0kA:
undetectable		 6av4A-2i0kA:
10.30
6av4B-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.37A 6av5A-2i0kA:
undetectable
6av5B-2i0kA:
undetectable		 6av5A-2i0kA:
10.30
6av5B-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 4 GLY A 435
ARG A 477
ASN A 516
LEU A 515
 None
CAC  A 705 ( 3.0A)
CAC  A 705 (-4.1A)
None
 1.42A 6b58A-2i0kA:
undetectable		 6b58A-2i0kA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.35A 6cicA-2i0kA:
undetectable
6cicB-2i0kA:
undetectable		 6cicA-2i0kA:
10.30
6cicB-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.36A 6cicA-2i0kA:
undetectable
6cicB-2i0kA:
undetectable		 6cicA-2i0kA:
10.30
6cicB-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 MET A 537
TRP A 536
PHE A 529
GLU A 534
 None
 1.31A 6cidA-2i0kA:
undetectable
6cidB-2i0kA:
undetectable		 6cidA-2i0kA:
10.30
6cidB-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		4 / 7 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.36A 6cidA-2i0kA:
undetectable
6cidB-2i0kA:
undetectable		 6cidA-2i0kA:
10.30
6cidB-2i0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2i0k OXIDOREDUCTASE
(Brevibacterium
sterolicum) 		3 / 3 TRP A 314
GLU A 319
GLU A 460
 None
 0.72A 6fhwA-2i0kA:
undetectable		 6fhwA-2i0kA:
10.93