SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		5 / 12 ILE A  83
LEU A  90
HIS A  10
HIS A 140
ILE A 200
 None
None
ZN  A 218 (-3.3A)
None
None
 1.06A 1fmlB-2i0mA:
undetectable		 1fmlB-2i0mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		5 / 12 ILE A 187
GLY A 180
SER A 176
ASN A 179
ILE A 166
 None
 1.21A 2e7fB-2i0mA:
undetectable		 2e7fB-2i0mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 7 ALA A 194
ASP A 195
GLY A 188
ILE A 187
 None
ZN  A 217 (-2.7A)
None
None
 0.89A 2fxdB-2i0mA:
undetectable		 2fxdB-2i0mA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 7 PHE A  16
PHE A 193
ILE A  45
GLY A  20
 None
 0.82A 2v0mB-2i0mA:
undetectable		 2v0mB-2i0mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 8 LEU A 134
LEU A 133
ALA A  27
PHE A 193
 None
 0.87A 2vcvF-2i0mA:
undetectable		 2vcvF-2i0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 8 LEU A 134
LEU A 133
ALA A  27
PHE A 193
 None
 0.75A 2vcvP-2i0mA:
undetectable		 2vcvP-2i0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 5 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.96A 3owxB-2i0mA:
undetectable		 3owxB-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 8 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.84A 4fglD-2i0mA:
undetectable		 4fglD-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 7 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.90A 4fglC-2i0mA:
undetectable		 4fglC-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		3 / 3 LEU A 190
MET A 122
ASP A  38
 None
 0.52A 4j7xB-2i0mA:
undetectable		 4j7xB-2i0mA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		5 / 12 LEU A  31
GLY A  94
ALA A  30
PHE A 193
GLY A  20
 None
 1.18A 4n09A-2i0mA:
undetectable		 4n09A-2i0mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		3 / 4 ARG A 192
GLY A 188
GLU A 191
 None
None
ZN  A 217 (-2.9A)
 0.64A 4z2dB-2i0mA:
0.8
4z2dC-2i0mA:
undetectable		 4z2dB-2i0mA:
18.59
4z2dC-2i0mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		3 / 3 PHE A 193
ASP A 195
LEU A 184
 None
ZN  A 217 (-2.7A)
None
 0.80A 5uhbC-2i0mA:
undetectable		 5uhbC-2i0mA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		3 / 3 PHE A 193
ASP A 195
LEU A 184
 None
ZN  A 217 (-2.7A)
None
 0.68A 5uhcC-2i0mA:
1.5		 5uhcC-2i0mA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
(Streptococcus
pneumoniae) 		4 / 8 GLN A 182
GLY A 180
ILE A 187
GLN A 118
 None
 0.91A 5vlmD-2i0mA:
1.9		 5vlmD-2i0mA:
21.36