SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		5 / 10 ARG A 453
SER A 496
GLY A 481
HIS A 480
ALA A 476
 None
 1.40A 1c9sG-2i0oA:
undetectable
1c9sH-2i0oA:
0.5		 1c9sG-2i0oA:
12.17
1c9sH-2i0oA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		5 / 10 ARG A 453
SER A 496
GLY A 481
HIS A 480
ALA A 476
 None
 1.40A 1gtfC-2i0oA:
0.5
1gtfD-2i0oA:
0.6		 1gtfC-2i0oA:
12.17
1gtfD-2i0oA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		5 / 12 PHE A  46
ALA A 408
ALA A  54
LEU A  22
PHE A  95
 None
 1.23A 1qabF-2i0oA:
undetectable		 1qabF-2i0oA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 5 MET A 570
ALA A 572
ILE A 520
ASP A 553
 None
 0.86A 1upfA-2i0oA:
undetectable		 1upfA-2i0oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 MET A 570
ALA A 572
ILE A 520
ASP A 553
 None
 0.83A 1upfB-2i0oA:
undetectable		 1upfB-2i0oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 5 MET A 570
ALA A 572
ILE A 520
ASP A 553
 None
 0.79A 1upfC-2i0oA:
undetectable		 1upfC-2i0oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 5 ASP A 479
GLY A 470
PRO A 445
ILE A 495
 None
 0.88A 2aofA-2i0oA:
undetectable		 2aofA-2i0oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 5 ASP A 479
GLY A 470
PRO A 445
ILE A 495
 None
 0.81A 2aoiA-2i0oA:
undetectable		 2aoiA-2i0oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 ASP A 479
GLY A 470
PRO A 445
ILE A 495
 None
 0.79A 2aojB-2i0oA:
undetectable		 2aojB-2i0oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 ALA A 476
GLY A 478
VAL A  64
ASP A  57
 None
None
None
ZN  A 580 (-2.1A)
 0.81A 2uyqA-2i0oA:
undetectable		 2uyqA-2i0oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		3 / 3 ASP A 500
THR A 525
GLU A 438
 None
 0.80A 2zifB-2i0oA:
undetectable		 2zifB-2i0oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 ASN A 422
ASP A 442
LYS A 444
SER A 426
 None
 1.38A 3lslA-2i0oA:
undetectable
3lslD-2i0oA:
undetectable		 3lslA-2i0oA:
22.07
3lslD-2i0oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 SER A 426
ASN A 422
ASP A 442
LYS A 444
 None
 1.39A 3lslA-2i0oA:
undetectable
3lslD-2i0oA:
undetectable		 3lslA-2i0oA:
22.07
3lslD-2i0oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		5 / 12 PHE A 441
LEU A 515
ILE A 477
ALA A 497
GLY A 424
 None
 1.04A 3nxuA-2i0oA:
undetectable		 3nxuA-2i0oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 SER A 426
GLY A 478
ASP A 479
GLU A  63
 None
 0.95A 4koeA-2i0oA:
undetectable
4koeB-2i0oA:
undetectable
4koeD-2i0oA:
undetectable		 4koeA-2i0oA:
22.16
4koeB-2i0oA:
22.16
4koeD-2i0oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		3 / 3 ASN A 472
ASP A 425
ASP A  38
 None
ZN  A 579 (-2.2A)
ZN  A 581 (-2.1A)
 0.85A 4obwD-2i0oA:
undetectable		 4obwD-2i0oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		5 / 12 CYH A 428
LEU A 515
VAL A 420
ALA A 411
ILE A 504
 None
 0.91A 4x20B-2i0oA:
undetectable		 4x20B-2i0oA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		4 / 7 GLY A 478
ASP A 479
GLU A  63
SER A 426
 None
 0.95A 4z53A-2i0oA:
undetectable
4z53B-2i0oA:
undetectable		 4z53A-2i0oA:
18.07
4z53B-2i0oA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2i0o SER/THR PHOSPHATASE
(Anopheles
gambiae) 		3 / 3 PHE A  52
ASP A  47
LYS A  77
 None
 0.88A 6awtD-2i0oA:
undetectable		 6awtD-2i0oA:
20.86