SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 4 ARG A 175
LEU A 184
ASN A 180
VAL A 176
 None
 1.40A 1lqtA-2i0sA:
undetectable		 1lqtA-2i0sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 4 ARG A 175
LEU A 184
ASN A 180
VAL A 176
 None
 1.39A 1lqtB-2i0sA:
undetectable		 1lqtB-2i0sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 4 ARG A 175
LEU A 184
ASN A 180
VAL A 176
 None
 1.40A 1lquA-2i0sA:
undetectable		 1lquA-2i0sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 4 ARG A 175
LEU A 184
ASN A 180
VAL A 176
 None
 1.39A 1lquB-2i0sA:
0.0		 1lquB-2i0sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 8 THR A 138
LEU A 163
VAL A 119
VAL A 127
 None
 0.86A 1t86A-2i0sA:
undetectable		 1t86A-2i0sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 7 GLY A 327
HIS A 353
TYR A 291
PRO A 274
 None
 1.12A 1th6A-2i0sA:
undetectable		 1th6A-2i0sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 7 GLY A 327
HIS A 353
TYR A 291
PRO A 274
 None
 1.12A 2armA-2i0sA:
undetectable		 2armA-2i0sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 8 THR A 249
VAL A 228
PHE A 300
ALA A 286
 None
 1.14A 2ij7C-2i0sA:
undetectable		 2ij7C-2i0sA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		7 / 9 PHE A  97
LEU A 100
PHE A 123
ASN A 124
GLN A 177
GLY A 178
LEU A 179
 None
 0.09A 2ok6B-2i0sA:
63.8
2ok6D-2i0sA:
undetectable		 2ok6B-2i0sA:
100.00
2ok6D-2i0sA:
15.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		7 / 10 PHE A  97
LEU A 100
PHE A 123
ASN A 124
GLN A 177
GLY A 178
LEU A 179
 None
 0.08A 2ok6A-2i0sA:
65.2
2ok6H-2i0sA:
undetectable		 2ok6A-2i0sA:
100.00
2ok6H-2i0sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		5 / 8 LEU A 313
ARG A 370
ALA A 372
GLY A 326
PRO A 325
 None
 1.30A 3ny4A-2i0sA:
undetectable		 3ny4A-2i0sA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		5 / 12 GLY A 326
ASP A 318
LEU A 313
ARG A 370
VAL A 342
 None
 1.11A 3o7wA-2i0sA:
undetectable		 3o7wA-2i0sA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 5 ILE A 194
GLN A 128
ILE A 136
GLU A 166
 None
 1.22A 4a99D-2i0sA:
undetectable		 4a99D-2i0sA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 8 GLY A 432
GLY A 431
VAL A 430
ASP A 385
 None
 0.80A 4qvvK-2i0sA:
undetectable
4qvvL-2i0sA:
undetectable		 4qvvK-2i0sA:
21.35
4qvvL-2i0sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 8 GLY A 432
GLY A 431
VAL A 430
ASP A 385
 None
 0.81A 4qvvY-2i0sA:
undetectable
4qvvZ-2i0sA:
undetectable		 4qvvY-2i0sA:
21.35
4qvvZ-2i0sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 6 ILE A 229
PRO A 230
ILE A 207
VAL A 219
 None
 0.96A 4zj8A-2i0sA:
undetectable		 4zj8A-2i0sA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2i0s AROMATIC AMINE
DEHYDROGENASE
(Alcaligenes
faecalis) 		4 / 6 GLU A 254
GLY A 253
GLY A 256
ASP A 255
 None
 1.03A 5a06D-2i0sA:
undetectable		 5a06D-2i0sA:
22.49