SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 7 THR A 129
LEU A  31
GLY A   9
LEU A  15
 None
None
FAD  A 501 (-3.3A)
None
 1.02A 1gtiE-2i0zA:
undetectable		 1gtiE-2i0zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 8 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.90A 1iwiA-2i0zA:
undetectable		 1iwiA-2i0zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 9 GLY A 177
GLU A 388
GLY A 164
GLY A 363
GLY A 362
 None
FAD  A 501 (-3.8A)
FAD  A 501 (-3.3A)
None
None
 0.98A 1mxdA-2i0zA:
undetectable		 1mxdA-2i0zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 THR A 414
PHE A  70
LEU A 390
VAL A 389
ALA A 162
 None
 1.28A 1q23D-2i0zA:
undetectable
1q23E-2i0zA:
undetectable		 1q23D-2i0zA:
19.86
1q23E-2i0zA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 8 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.81A 1t86A-2i0zA:
undetectable		 1t86A-2i0zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 ALA A 184
ILE A 136
ALA A 181
SER A 377
PHE A 385
 None
 1.08A 1ve3A-2i0zA:
3.2		 1ve3A-2i0zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		3 / 3 ARG A 206
GLU A 317
SER A 200
 None
 0.92A 2xkkA-2i0zA:
undetectable
2xkkC-2i0zA:
undetectable		 2xkkA-2i0zA:
21.04
2xkkC-2i0zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 4 SER A 354
GLY A 362
GLY A 165
LYS A 166
 None
 1.35A 2y4nB-2i0zA:
undetectable		 2y4nB-2i0zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 6 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.89A 2z97A-2i0zA:
undetectable		 2z97A-2i0zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A  10
VAL A   7
VAL A 160
LEU A 120
ILE A 127
 FAD  A 501 ( 4.5A)
None
None
None
None
 1.04A 3ku1H-2i0zA:
2.3		 3ku1H-2i0zA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 11 THR A 407
ALA A 411
GLY A 164
ALA A 162
SER A 403
 None
None
FAD  A 501 (-3.3A)
None
None
 1.20A 3mg0N-2i0zA:
undetectable		 3mg0N-2i0zA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 VAL A 112
ASN A  50
CYH A  49
LEU A 405
ILE A  83
 None
CL  A 424 (-4.8A)
None
None
None
 1.43A 4kukA-2i0zA:
undetectable		 4kukA-2i0zA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 8 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.82A 4l4bA-2i0zA:
undetectable		 4l4bA-2i0zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 HIS A 186
SER A 173
LEU A 390
THR A 361
SER A 167
 None
FAD  A 501 ( 3.9A)
None
None
FAD  A 501 ( 4.5A)
 1.17A 4pooA-2i0zA:
2.2		 4pooA-2i0zA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 8 LEU A  15
VAL A 125
VAL A   7
LEU A 117
 None
 0.96A 4puoC-2i0zA:
undetectable		 4puoC-2i0zA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 8 LEU A  15
VAL A 125
VAL A   7
LEU A 117
 None
 0.98A 4pwdA-2i0zA:
undetectable		 4pwdA-2i0zA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A 243
TYR A 311
LEU A 213
PHE A 204
LEU A 220
 None
 1.48A 4xldA-2i0zA:
undetectable		 4xldA-2i0zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 LEU A  29
LEU A 154
ILE A   6
ILE A 136
VAL A 133
 None
None
None
None
FAD  A 501 (-3.9A)
 0.98A 4y0sA-2i0zA:
undetectable		 4y0sA-2i0zA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 6 LEU A  41
PRO A 104
PHE A 103
GLU A  97
 None
 1.26A 5b8iA-2i0zA:
undetectable		 5b8iA-2i0zA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A 387
ILE A 401
LEU A 405
GLY A  11
GLY A 175
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.6A)
None
FAD  A 501 (-3.4A)
None
 1.01A 5d4uA-2i0zA:
2.9		 5d4uA-2i0zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A 387
ILE A 401
LEU A 405
GLY A  11
GLY A 175
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.6A)
None
FAD  A 501 (-3.4A)
None
 0.99A 5d4uB-2i0zA:
2.7		 5d4uB-2i0zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A 387
ILE A 401
LEU A 405
GLY A  11
GLY A 175
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.6A)
None
FAD  A 501 (-3.4A)
None
 0.99A 5d4uC-2i0zA:
2.9		 5d4uC-2i0zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 LEU A  94
ASP A 122
THR A 118
PRO A  12
PHE A  87
 None
None
None
FAD  A 501 (-3.6A)
None
 1.34A 5dlvA-2i0zA:
undetectable		 5dlvA-2i0zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 LEU A  94
ASP A 122
THR A 118
PRO A  12
PHE A  87
 None
None
None
FAD  A 501 (-3.6A)
None
 1.32A 5dlvB-2i0zA:
undetectable		 5dlvB-2i0zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		3 / 3 PRO A 193
ILE A 231
SER A 354
 None
 0.80A 5fsaA-2i0zA:
undetectable		 5fsaA-2i0zA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 4 CYH A  49
PHE A 103
ILE A  83
GLY A 398
 None
None
None
FAD  A 501 ( 3.3A)
 0.98A 5hesB-2i0zA:
0.0		 5hesB-2i0zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		6 / 12 LEU A 338
ILE A 335
LEU A 275
LEU A 283
LEU A 288
MET A 287
 None
 1.32A 5nfjA-2i0zA:
2.2		 5nfjA-2i0zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 LEU A  31
ILE A   8
GLY A   9
LEU A 148
VAL A 133
 None
None
FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.9A)
 1.16A 5twjC-2i0zA:
undetectable		 5twjC-2i0zA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		6 / 11 LEU A  31
ILE A   8
GLY A   9
GLY A  10
LEU A 148
VAL A 133
 None
None
FAD  A 501 (-3.3A)
FAD  A 501 ( 4.5A)
None
FAD  A 501 (-3.9A)
 1.42A 5twjD-2i0zA:
undetectable		 5twjD-2i0zA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		5 / 12 GLY A 164
VAL A 112
LEU A 116
SER A 403
ILE A 401
 FAD  A 501 (-3.3A)
None
None
None
FAD  A 501 (-3.6A)
 1.16A 5vopB-2i0zA:
undetectable		 5vopB-2i0zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 7 ILE A 401
LEU A 405
ARG A 101
LEU A  94
 FAD  A 501 (-3.6A)
None
None
None
 0.98A 5zcpA-2i0zA:
undetectable
5zcpJ-2i0zA:
undetectable		 5zcpA-2i0zA:
22.40
5zcpJ-2i0zA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 6 ALA A  17
GLY A 164
ILE A 392
PHE A  70
 None
FAD  A 501 (-3.3A)
None
None
 0.82A 6f8cA-2i0zA:
undetectable		 6f8cA-2i0zA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES
(Bacillus
cereus) 		4 / 7 VAL A  61
ILE A 392
MET A  16
GLY A  20
 None
 0.75A 6hd6B-2i0zA:
undetectable		 6hd6B-2i0zA:
11.19