SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A  89
GLY A  91
LEU A  72
PHE A  88
MET A 132
 None
 1.28A 3h52C-2i10A:
undetectable		 3h52C-2i10A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A  89
GLY A  91
VAL A  95
LEU A  72
MET A 132
 None
 1.46A 3h52C-2i10A:
undetectable		 3h52C-2i10A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 7 VAL A 162
VAL A 166
LEU A 169
SER A 170
 None
 0.79A 3hs6B-2i10A:
undetectable		 3hs6B-2i10A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 GLU A  58
LEU A  61
ASP A  62
 None
 0.48A 3ko0A-2i10A:
1.3		 3ko0A-2i10A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 GLU A  58
LEU A  61
ASP A  62
 None
 0.42A 3ko0T-2i10A:
undetectable		 3ko0T-2i10A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A  56
ILE A  32
LEU A  39
LEU A  21
ALA A  18
 None
 0.98A 4p65B-2i10A:
undetectable
4p65D-2i10A:
undetectable
4p65I-2i10A:
undetectable
4p65J-2i10A:
undetectable		 4p65B-2i10A:
10.29
4p65D-2i10A:
10.29
4p65I-2i10A:
12.96
4p65J-2i10A:
10.29