SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 337
ASN A 338
GLY A 320
GLY A 309
 None
 0.74A 1rukH-2i14A:
undetectable
1rukL-2i14A:
undetectable		 1rukH-2i14A:
16.33
1rukL-2i14A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 8 ALA A 295
GLY A 289
GLY A 135
ILE A 136
ALA A 150
 None
PCP  A 392 (-3.3A)
None
None
None
 1.32A 1sguA-2i14A:
undetectable		 1sguA-2i14A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 0.95A 2bfpA-2i14A:
1.2		 2bfpA-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 0.97A 2bfpB-2i14A:
undetectable		 2bfpB-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 0.97A 2bfpC-2i14A:
undetectable		 2bfpC-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 1.00A 2bfpD-2i14A:
undetectable		 2bfpD-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		6 / 6 PHE A 134
ARG A 137
SER A 160
GLY A 174
THR A 175
ARG A 233
 PCP  A 392 (-4.2A)
PCP  A 392 (-2.8A)
None
None
None
PCP  A 392 (-4.0A)
 0.83A 2f7fA-2i14A:
36.0		 2f7fA-2i14A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 9 PRO A 357
ILE A 358
GLY A  68
ASN A 361
GLU A 360
 None
 1.47A 2pivA-2i14A:
0.0		 2pivA-2i14A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 118
THR A 117
ALA A 116
PRO A  48
 None
 0.80A 2ql8A-2i14A:
undetectable
2ql8B-2i14A:
undetectable		 2ql8A-2i14A:
17.35
2ql8B-2i14A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 7 ALA A 144
GLY A 164
ASP A 148
VAL A 159
ARG A 137
 None
None
None
None
PCP  A 392 (-2.8A)
 1.38A 2uyqA-2i14A:
undetectable		 2uyqA-2i14A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 131
GLY A 135
GLY A 289
ILE A 122
ALA A 151
 None
None
PCP  A 392 (-3.3A)
None
None
 0.93A 2z0yB-2i14A:
undetectable		 2z0yB-2i14A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 148
ILE A 292
VAL A 131
THR A 175
 None
 1.19A 3eigA-2i14A:
undetectable		 3eigA-2i14A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 THR A  17
THR A  18
THR A 103
LEU A  65
LEU A  23
 None
 1.43A 3gwxB-2i14A:
undetectable		 3gwxB-2i14A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		6 / 9 GLY A 290
ALA A 291
ASP A 272
ILE A 276
GLY A 269
ILE A 122
 PCP  A 392 (-3.6A)
None
None
None
PCP  A 392 ( 4.1A)
None
 1.27A 3nu4B-2i14A:
undetectable		 3nu4B-2i14A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 153
ILE A  12
THR A  17
ILE A  91
ILE A 359
 None
 1.17A 3prsA-2i14A:
undetectable		 3prsA-2i14A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 8 GLY A 135
GLY A 287
ILE A 122
LEU A 271
VAL A 131
 None
 1.37A 3v1nA-2i14A:
undetectable		 3v1nA-2i14A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 7 THR A  80
HIS A  83
TYR A 332
TYR A 377
 None
 1.39A 4a3uA-2i14A:
3.4		 4a3uA-2i14A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 265
PHE A 266
PHE A 134
LEU A 234
VAL A 208
 None
None
PCP  A 392 (-4.2A)
None
None
 1.07A 4g1bD-2i14A:
undetectable		 4g1bD-2i14A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 273
TRP A  51
LYS A 275
 None
 1.30A 4k7aA-2i14A:
undetectable		 4k7aA-2i14A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 289
GLY A 290
ILE A 292
GLY A 161
ILE A 147
 PCP  A 392 (-3.3A)
PCP  A 392 (-3.6A)
None
None
None
 1.09A 4qoiA-2i14A:
undetectable
4qoiB-2i14A:
undetectable		 4qoiA-2i14A:
20.65
4qoiB-2i14A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
 None
None
None
None
PCP  A 392 (-3.3A)
 1.21A 5i71A-2i14A:
undetectable		 5i71A-2i14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
 None
None
None
None
PCP  A 392 (-3.3A)
 1.17A 5i75A-2i14A:
undetectable		 5i75A-2i14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  58
ILE A 374
ALA A 150
ALA A 116
ILE A 153
 None
 0.91A 5kb6A-2i14A:
undetectable		 5kb6A-2i14A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  58
ILE A 374
ALA A 150
ALA A 116
ILE A 153
 None
 0.92A 5kb6B-2i14A:
undetectable		 5kb6B-2i14A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 304
MET A 108
ILE A 358
ALA A  75
LEU A  89
 None
 1.12A 5oy02-2i14A:
undetectable		 5oy02-2i14A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 THR A  80
HIS A  83
TYR A 332
TYR A 377
 None
 1.30A 5v4vA-2i14A:
3.5		 5v4vA-2i14A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 THR A  80
HIS A  83
TYR A 332
TYR A 377
 None
 1.30A 5v4vB-2i14A:
3.9		 5v4vB-2i14A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 6 TYR A 377
GLU A 380
GLN A 381
LYS A 384
 None
 1.02A 6d8pA-2i14A:
0.0		 6d8pA-2i14A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 5 VAL A 298
LEU A  47
HIS A  83
THR A 117
 None
 1.46A 6dyoA-2i14A:
undetectable		 6dyoA-2i14A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 298
GLY A 164
ARG A 121
ALA A 150
 None
 0.88A 6hd6B-2i14A:
undetectable		 6hd6B-2i14A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 155
VAL A 159
GLY A  79
ALA A 112
 None
 0.73A 6hu9H-2i14A:
undetectable
6hu9e-2i14A:
undetectable		 6hu9H-2i14A:
13.07
6hu9e-2i14A:
14.44