SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2i1j MOESIN
(Spodoptera
frugiperda) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.15A 1fduC-2i1jA:
undetectable		 1fduC-2i1jA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 None
 1.27A 1lqtA-2i1jA:
undetectable		 1lqtA-2i1jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 None
 1.27A 1lquA-2i1jA:
undetectable		 1lquA-2i1jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2i1j MOESIN
(Spodoptera
frugiperda) 		5 / 12 ASN A 226
LEU A 218
GLY A 219
THR A 556
ILE A 560
 None
 1.42A 1p93A-2i1jA:
3.1		 1p93A-2i1jA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 LEU A 152
ASP A 150
GLY A 135
ALA A 126
 URE  A 578 (-4.7A)
None
None
None
 0.82A 2aohB-2i1jA:
undetectable		 2aohB-2i1jA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 7 LYS A   3
ILE A  20
GLN A  21
LEU A 344
 None
 0.87A 3bjwB-2i1jA:
undetectable		 3bjwB-2i1jA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 8 ARG A 558
ASP A 197
GLN A 196
GLU A 190
 None
 1.24A 3dh0A-2i1jA:
undetectable		 3dh0A-2i1jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 4 VAL A   7
PHE A  78
PHE A  80
VAL A  34
 None
 1.42A 3rv5C-2i1jA:
0.7
3rv5D-2i1jA:
0.9		 3rv5C-2i1jA:
8.93
3rv5D-2i1jA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2i1j MOESIN
(Spodoptera
frugiperda) 		5 / 9 PHE A  78
VAL A  33
ILE A  59
GLY A  26
THR A  24
 None
 1.37A 3t3rC-2i1jA:
undetectable		 3t3rC-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 LEU A 557
PRO A 502
VAL A 503
ASP A 221
 None
 1.09A 3ufnA-2i1jA:
undetectable
3ufnB-2i1jA:
undetectable		 3ufnA-2i1jA:
9.76
3ufnB-2i1jA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2i1j MOESIN
(Spodoptera
frugiperda) 		5 / 12 ASN A 138
GLY A 135
ALA A 148
GLY A 145
ASN A 149
 None
 1.25A 3v3oA-2i1jA:
undetectable		 3v3oA-2i1jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 GLY A  38
LEU A  16
TYR A 340
GLU A 339
 None
 1.11A 3w9tB-2i1jA:
undetectable		 3w9tB-2i1jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 GLY A  38
LEU A  16
TYR A 340
GLU A 339
 None
 1.11A 3w9tE-2i1jA:
undetectable		 3w9tE-2i1jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 GLY A  38
LEU A  16
TYR A 340
GLU A 339
 None
 1.14A 3w9tF-2i1jA:
undetectable		 3w9tF-2i1jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 LEU A 216
TYR A 116
MET A 539
ARG A 568
 None
 1.44A 4bkjB-2i1jA:
undetectable		 4bkjB-2i1jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 8 VAL A 130
ILE A 110
VAL A 157
THR A 158
 None
 0.94A 4ma7A-2i1jA:
undetectable		 4ma7A-2i1jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 ILE A 194
ARG A 512
ASP A  88
VAL A 106
 None
 1.03A 4nkxC-2i1jA:
undetectable		 4nkxC-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 ILE A 194
ARG A 512
ASP A  88
VAL A 106
 None
 1.08A 4nkxD-2i1jA:
undetectable		 4nkxD-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.09A 4yv5B-2i1jA:
undetectable		 4yv5B-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.10A 4yv5A-2i1jA:
undetectable		 4yv5A-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.18A 5dzkb-2i1jA:
undetectable
5dzkp-2i1jA:
undetectable		 5dzkb-2i1jA:
16.75
5dzkp-2i1jA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.21A 5dzkc-2i1jA:
undetectable
5dzkq-2i1jA:
undetectable		 5dzkc-2i1jA:
16.75
5dzkq-2i1jA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 7 ILE A  37
GLY A  38
LEU A 290
PHE A  84
 None
 0.84A 5hieB-2i1jA:
undetectable		 5hieB-2i1jA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2i1j MOESIN
(Spodoptera
frugiperda) 		3 / 3 LYS A 254
LEU A 218
ILE A 248
 None
 0.76A 5kc0A-2i1jA:
undetectable		 5kc0A-2i1jA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2i1j MOESIN
(Spodoptera
frugiperda) 		3 / 3 ARG A  40
LYS A  35
ARG A 353
 None
 0.75A 6c06D-2i1jA:
undetectable		 6c06D-2i1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2i1j MOESIN
(Spodoptera
frugiperda) 		3 / 3 ARG A 506
LYS A 553
ARG A 156
 None
 1.37A 6c06D-2i1jA:
undetectable		 6c06D-2i1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 None
 0.71A 6g1pA-2i1jA:
undetectable		 6g1pA-2i1jA:
20.85