SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		4 / 4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.28A 1mj2B-2i1nA:
undetectable		 1mj2B-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		4 / 4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.28A 1mj2D-2i1nA:
undetectable		 1mj2D-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		4 / 4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.26A 1mjoB-2i1nA:
undetectable		 1mjoB-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		4 / 4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.29A 1mjoA-2i1nA:
undetectable		 1mjoA-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		4 / 4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.28A 1mjoD-2i1nA:
undetectable		 1mjoD-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 142
ALA A 171
ASP A 174
ILE A 132
VAL A 179
ILE A 165
 None
 1.31A 1muiB-2i1nA:
undetectable		 1muiB-2i1nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 142
ALA A 171
ASP A 174
ILE A 132
ILE A 145
ILE A 165
 None
 1.33A 2nmzA-2i1nA:
undetectable		 2nmzA-2i1nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 142
ALA A 171
ASP A 174
ILE A 132
ILE A 145
ILE A 165
 None
 1.31A 2nmzB-2i1nA:
undetectable		 2nmzB-2i1nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 142
ALA A 171
ASP A 174
ILE A 132
VAL A 179
ILE A 165
 None
 1.24A 3d1yA-2i1nA:
undetectable		 3d1yA-2i1nA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 169
ALA A 171
ASP A 174
ILE A 132
VAL A 179
ILE A 165
 None
 1.46A 3k4vA-2i1nA:
undetectable		 3k4vA-2i1nA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2i1n DISCS, LARGE HOMOLOG
3
(Homo
sapiens) 		6 / 12 GLY A 142
ALA A 171
ASP A 174
ILE A 132
VAL A 179
ILE A 165
 None
 1.24A 3tkwB-2i1nA:
undetectable		 3tkwB-2i1nA:
19.63