SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 HIS A  38
GLU A  54
ASP A  49
LEU A  35
GLY A  69
 None
 1.26A 1d4fB-2i1sA:
undetectable		 1d4fB-2i1sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 HIS A  38
GLU A  54
ASP A  49
LEU A  35
GLY A  69
 None
 1.23A 1d4fC-2i1sA:
undetectable		 1d4fC-2i1sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 HIS A  38
GLU A  54
ASP A  49
LEU A  35
GLY A  69
 None
 1.21A 1d4fD-2i1sA:
undetectable		 1d4fD-2i1sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 9 LEU A  65
LYS A  67
ILE A  68
PHE A  55
PHE A  34
 None
 1.45A 1td7A-2i1sA:
undetectable		 1td7A-2i1sA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 0.86A 2oipE-2i1sA:
undetectable		 2oipE-2i1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.05A 3hj3B-2i1sA:
undetectable		 3hj3B-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.02A 4ky8A-2i1sA:
undetectable		 4ky8A-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.07A 4ky8B-2i1sA:
undetectable		 4ky8B-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.05A 4ky8C-2i1sA:
undetectable		 4ky8C-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.07A 4ky8D-2i1sA:
undetectable		 4ky8D-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.04A 4ky8E-2i1sA:
undetectable		 4ky8E-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.14A 4q0dA-2i1sA:
undetectable		 4q0dA-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.14A 4q0dB-2i1sA:
undetectable		 4q0dB-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 101
LEU A  11
LEU A  90
LYS A  89
ILE A 120
 None
 1.14A 4q0dE-2i1sA:
undetectable		 4q0dE-2i1sA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2i1s HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 12 ARG A 137
PHE A 181
PHE A 176
ILE A  26
ALA A  40
 None
 1.05A 5vc0A-2i1sA:
undetectable		 5vc0A-2i1sA:
16.98