SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 744
VAL A 798
MET A 797
ILE A 751
 None
 1.13A 2hyyC-2i1yA:
undetectable		 2hyyC-2i1yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 6 ARG A 750
ASP A 747
THR A 728
ASP A 763
 None
 1.00A 2j2pE-2i1yA:
undetectable
2j2pF-2i1yA:
undetectable		 2j2pE-2i1yA:
20.00
2j2pF-2i1yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		5 / 9 THR A 884
LEU A 963
ALA A 965
LEU A 921
LEU A 888
 None
 1.30A 2npnA-2i1yA:
3.5		 2npnA-2i1yA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASN A 738
ASN A 766
ARG A 949
 None
 0.60A 2rlcA-2i1yA:
undetectable		 2rlcA-2i1yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 TYR A 823
VAL A 907
CYH A 803
ILE A 781
 None
 1.34A 2xz5B-2i1yA:
undetectable
2xz5E-2i1yA:
undetectable		 2xz5B-2i1yA:
21.36
2xz5E-2i1yA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 750
ASP A 793
ASN A 734
 None
 0.83A 2zzmA-2i1yA:
undetectable		 2zzmA-2i1yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 THR A 884
SER A 883
PHE A 849
 None
 0.90A 3d4sA-2i1yA:
undetectable		 3d4sA-2i1yA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 5 PRO A 769
ILE A 781
PRO A 904
TYR A 780
 None
 1.03A 3d9lA-2i1yA:
undetectable
3d9lY-2i1yA:
undetectable		 3d9lA-2i1yA:
18.71
3d9lY-2i1yA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 5 HIS A 748
ASP A 747
TYR A 746
PRO A 950
 None
 1.27A 3fo7A-2i1yA:
undetectable		 3fo7A-2i1yA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 5 HIS A 748
ASP A 747
TYR A 746
PRO A 950
 None
 1.24A 3h1xA-2i1yA:
undetectable		 3h1xA-2i1yA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 5 LEU A 812
ILE A 791
PRO A 786
PHE A 794
 None
 1.23A 3s3vA-2i1yA:
undetectable		 3s3vA-2i1yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 785
ARG A 739
GLY A 912
ARG A 822
ASP A 821
 None
 1.14A 3tkaA-2i1yA:
undetectable		 3tkaA-2i1yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASN A 895
ASP A 923
ASN A 927
 None
 0.74A 4agaA-2i1yA:
undetectable		 4agaA-2i1yA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 ARG A 822
VAL A 840
PHE A 854
GLU A 836
 None
 1.25A 4jseA-2i1yA:
undetectable
4jseB-2i1yA:
undetectable		 4jseA-2i1yA:
21.18
4jseB-2i1yA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 PHE A 854
GLU A 836
ARG A 822
VAL A 840
 None
 1.20A 4jseA-2i1yA:
undetectable
4jseB-2i1yA:
undetectable		 4jseA-2i1yA:
21.18
4jseB-2i1yA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 MET A 797
ARG A 949
VAL A 907
MET A 808
 None
 1.49A 4klaA-2i1yA:
0.0		 4klaA-2i1yA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 946
LEU A 942
GLU A 943
 None
 0.76A 4l3gF-2i1yA:
undetectable		 4l3gF-2i1yA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A 760
SER A 762
GLU A 800
ASP A 793
 None
 1.39A 4ymgA-2i1yA:
0.0		 4ymgA-2i1yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 729
ASP A 911
ARG A 954
GLY A 951
 None
 0.91A 5bs8A-2i1yA:
undetectable
5bs8C-2i1yA:
undetectable
5bs8D-2i1yA:
2.4		 5bs8A-2i1yA:
21.97
5bs8C-2i1yA:
21.97
5bs8D-2i1yA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 729
ASP A 911
ARG A 954
GLY A 951
 None
 0.94A 5bs8A-2i1yA:
undetectable
5bs8B-2i1yA:
undetectable
5bs8C-2i1yA:
undetectable		 5bs8A-2i1yA:
21.97
5bs8B-2i1yA:
24.55
5bs8C-2i1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 729
ASP A 911
ARG A 954
GLY A 951
 None
 0.93A 5btdA-2i1yA:
undetectable
5btdB-2i1yA:
2.2
5btdC-2i1yA:
undetectable		 5btdA-2i1yA:
21.97
5btdB-2i1yA:
24.55
5btdC-2i1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 729
ASP A 911
ARG A 954
GLY A 951
 None
 0.90A 5btdA-2i1yA:
undetectable
5btdC-2i1yA:
undetectable
5btdD-2i1yA:
2.4		 5btdA-2i1yA:
21.97
5btdC-2i1yA:
21.97
5btdD-2i1yA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 922
THR A 884
ALA A 962
LEU A 921
VAL A 953
 None
 1.26A 5hw4A-2i1yA:
2.9		 5hw4A-2i1yA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 806
TYR A 823
HIS A 908
SER A 768
ILE A 751
 None
 1.34A 5igwA-2i1yA:
undetectable		 5igwA-2i1yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 899
PRO A 778
ASN A 927
 None
 1.07A 5jwaA-2i1yA:
undetectable
5jwaH-2i1yA:
undetectable		 5jwaA-2i1yA:
18.02
5jwaH-2i1yA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens) 		4 / 8 TYR A 823
THR A 783
CYH A 803
TRP A 795
 None
 1.17A 6cnjD-2i1yA:
undetectable
6cnjE-2i1yA:
undetectable		 6cnjD-2i1yA:
12.41
6cnjE-2i1yA:
14.43