SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JJ8_B_AZZB1211_1 (DEOXYNUCLEOSIDE KINASE)	2i2r	KV CHANNEL-INTERACTING PROTEIN 1 (Homo sapiens)	5 / 12	LEU E 94 TYR E 78 PHE E 74 VAL E 106 PHE E 111	None	1.28A	2jj8B-2i2rE: undetectable	2jj8B-2i2rE: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	2i2r	KV CHANNEL-INTERACTING PROTEIN 1 (Homo sapiens)	4 / 6	ILE E 154 THR E 130 PHE E 195 PHE E 178	None	1.32A	3elzB-2i2rE: undetectable	3elzB-2i2rE: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WMZ_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2i2r	KV CHANNEL-INTERACTING PROTEIN 1 (Homo sapiens)	5 / 9	PHE E 74 ILE E 77 TYR E 78 PHE E 98 LEU E 115	None	1.44A	4wmzA-2i2rE: 0.0	4wmzA-2i2rE: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESF_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2i2r	KV CHANNEL-INTERACTING PROTEIN 1 (Homo sapiens)	5 / 8	PHE E 74 ILE E 77 TYR E 78 PHE E 98 LEU E 115	None	1.43A	5esfA-2i2rE: undetectable	5esfA-2i2rE: 15.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JJ8_B_AZZB1211_1","DEOXYNUCLEOSIDE KINASE","2i2r","KV CHANNEL-INTERACTING PROTEIN 1","Homo sapiens",5,"LEU E  94;TYR E  78;PHE E  74;VAL E 106;PHE E 111","None","1.28A","2jj8B-2i2rE:undetectable","2jj8B-2i2rE:20.08"],["3ELZ_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","2i2r","KV CHANNEL-INTERACTING PROTEIN 1","Homo sapiens",4,"ILE E 154;THR E 130;PHE E 195;PHE E 178","None","1.32A","3elzB-2i2rE:undetectable","3elzB-2i2rE:20.90"],["4WMZ_A_TPFA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2i2r","KV CHANNEL-INTERACTING PROTEIN 1","Homo sapiens",5,"PHE E  74;ILE E  77;TYR E  78;PHE E  98;LEU E 115","None","1.44A","4wmzA-2i2rE:0.0","4wmzA-2i2rE:15.62"],["5ESF_A_TPFA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2i2r","KV CHANNEL-INTERACTING PROTEIN 1","Homo sapiens",5,"PHE E  74;ILE E  77;TYR E  78;PHE E  98;LEU E 115","None","1.43A","5esfA-2i2rE:undetectable","5esfA-2i2rE:15.81"]]