SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 10 ALA A  79
PHE A  41
ALA A  59
LEU A 144
ILE A 179
 None
 1.34A 1claA-2i2wA:
undetectable		 1claA-2i2wA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLU A 106
VAL A  85
ASP A  99
ILE A 100
ASN A 126
 None
 1.31A 3jayA-2i2wA:
undetectable		 3jayA-2i2wA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 TYR A 104
ALA A  59
ALA A  63
THR A  67
 None
 0.70A 3l4dA-2i2wA:
undetectable		 3l4dA-2i2wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 ILE A 160
VAL A 162
ILE A 171
SER A  55
LEU A 116
 None
 1.22A 4a84A-2i2wA:
undetectable		 4a84A-2i2wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 TYR A 104
LEU A  48
ARG A 110
ALA A  63
THR A  67
 None
 1.08A 4fiaA-2i2wA:
undetectable		 4fiaA-2i2wA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 TYR A 104
LEU A  48
ARG A 110
ALA A  63
THR A  67
 None
 1.08A 4fiaA-2i2wA:
undetectable		 4fiaA-2i2wA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 SER A 121
SER A 119
ILE A 128
GLU A 159
 None
 1.34A 4ms4A-2i2wA:
3.9		 4ms4A-2i2wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 ALA A  34
ALA A  33
GLN A  31
ILE A 176
LEU A 144
 None
 1.10A 4nqaH-2i2wA:
undetectable		 4nqaH-2i2wA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 ASN A 126
ILE A 100
GLY A  51
VAL A  47
 None
 0.83A 4r20A-2i2wA:
undetectable		 4r20A-2i2wA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2i2w PHOSPHOHEPTOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 ILE A  82
ILE A  80
LEU A  48
SER A  86
VAL A  85
 None
 1.12A 5km9B-2i2wA:
undetectable		 5km9B-2i2wA:
21.33