SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLU B 165
LEU B 157
ARG A 133
LEU B 178
 None
 0.97A 1ereE-2i2xB:
undetectable		 1ereE-2i2xB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLU B 165
LEU B 157
ARG A 133
LEU B 178
 None
 0.97A 1ereF-2i2xB:
undetectable		 1ereF-2i2xB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 4 LYS A 277
ALA A 278
MET A  17
 None
 1.05A 1hk3A-2i2xA:
0.9		 1hk3A-2i2xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 GLU A  42
GLU A 313
GLU A  84
GLU A  86
 None
K  A 511 (-3.6A)
None
K  A 511 (-2.6A)
 1.08A 1knyA-2i2xA:
undetectable
1knyB-2i2xA:
undetectable		 1knyA-2i2xA:
19.35
1knyB-2i2xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLU A  86
GLU A  84
ASP A 297
GLU A 164
 K  A 511 (-2.6A)
None
None
ZN  A 501 ( 2.3A)
 1.16A 1knyA-2i2xA:
undetectable
1knyB-2i2xA:
undetectable		 1knyA-2i2xA:
19.35
1knyB-2i2xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 LYS B  45
GLU B  49
ALA B  44
VAL B  83
 None
 1.16A 1sn5A-2i2xB:
undetectable		 1sn5A-2i2xB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 LEU A 147
PHE A 146
ARG A 123
 None
 0.88A 1xdkB-2i2xA:
undetectable		 1xdkB-2i2xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 ARG A   5
VAL A 276
GLY A 264
 None
 0.62A 2avvE-2i2xA:
undetectable		 2avvE-2i2xA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 VAL A 378
SER A 381
ALA A 397
PRO A 252
 None
 0.95A 2v41G-2i2xA:
undetectable
2v41H-2i2xA:
undetectable		 2v41G-2i2xA:
19.65
2v41H-2i2xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 ALA A 396
ALA A 393
GLY A 386
GLY A 379
ILE A 275
 None
 1.06A 2x1lB-2i2xA:
2.2		 2x1lB-2i2xA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 11 ALA A 396
ALA A 393
GLY A 386
GLY A 379
ILE A 275
 None
 1.03A 2x1lC-2i2xA:
undetectable		 2x1lC-2i2xA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASP A  68
THR A  66
TYR A  45
HIS A 103
 None
 1.37A 2y69A-2i2xA:
0.6
2y69C-2i2xA:
undetectable		 2y69A-2i2xA:
23.10
2y69C-2i2xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 GLU A  86
ASN A  44
SER A 311
GLU A 272
GLU A 164
 K  A 511 (-2.6A)
None
None
None
ZN  A 501 ( 2.3A)
 1.34A 2zq0A-2i2xA:
0.6		 2zq0A-2i2xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP A  68
THR A  66
TYR A  45
HIS A 103
 None
 1.39A 2zxwA-2i2xA:
undetectable
2zxwC-2i2xA:
undetectable		 2zxwA-2i2xA:
23.10
2zxwC-2i2xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 PRO A  95
ALA A  99
ALA A 102
GLU A 148
 None
 0.73A 3dtuC-2i2xA:
undetectable
3dtuD-2i2xA:
undetectable		 3dtuC-2i2xA:
20.47
3dtuD-2i2xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 11 GLY A 157
ALA A 158
ILE A 213
GLY A  29
LEU A  30
 None
 0.91A 3em4A-2i2xA:
undetectable		 3em4A-2i2xA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 ASN A 273
ASP A 268
ARG A 130
 None
 0.70A 3k13C-2i2xA:
7.9		 3k13C-2i2xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLY A 288
ILE A 274
CYH A 306
PHE A  19
 None
 0.93A 3ko0O-2i2xA:
undetectable
3ko0Q-2i2xA:
undetectable		 3ko0O-2i2xA:
13.19
3ko0Q-2i2xA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLY A 300
ILE A 274
CYH A 306
PHE A  19
 None
 0.96A 3ko0O-2i2xA:
undetectable
3ko0Q-2i2xA:
undetectable		 3ko0O-2i2xA:
13.19
3ko0Q-2i2xA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 GLU A 272
GLU A 313
ASN A 224
 None
K  A 511 (-3.6A)
None
 0.88A 3lp9B-2i2xA:
undetectable
3lp9D-2i2xA:
undetectable		 3lp9B-2i2xA:
19.69
3lp9D-2i2xA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 GLY B 210
ILE B 142
VAL B 143
 B13  B 500 (-3.6A)
B13  B 500 ( 4.4A)
None
 0.45A 3nv6A-2i2xB:
undetectable		 3nv6A-2i2xB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		3 / 3 GLY B 228
ILE B 142
VAL B 143
 B13  B 500 (-4.4A)
B13  B 500 ( 4.4A)
None
 0.47A 3nv6A-2i2xB:
undetectable		 3nv6A-2i2xB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASP A 268
GLY A 266
GLU A 287
ARG A 253
 None
 1.03A 3s3nA-2i2xA:
undetectable		 3s3nA-2i2xA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 9 LEU A 161
ILE A 108
MET A 109
ILE A  81
ILE A  43
 None
 1.29A 3zosB-2i2xA:
undetectable		 3zosB-2i2xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 MET A 440
ILE A 389
ARG A   5
PRO A 456
 None
 1.30A 4f4dB-2i2xA:
undetectable		 4f4dB-2i2xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.14A 4feuB-2i2xA:
undetectable		 4feuB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.11A 4feuF-2i2xA:
0.3		 4feuF-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.16A 4fevB-2i2xA:
undetectable		 4fevB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.15A 4fevD-2i2xA:
undetectable		 4fevD-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.13A 4fevF-2i2xA:
undetectable		 4fevF-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.10A 4fewB-2i2xA:
undetectable		 4fewB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.18A 4fewD-2i2xA:
undetectable		 4fewD-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.18A 4fewF-2i2xA:
undetectable		 4fewF-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.11A 4fexB-2i2xA:
undetectable		 4fexB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.16A 4gkhB-2i2xA:
undetectable		 4gkhB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.08A 4gkhD-2i2xA:
undetectable		 4gkhD-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.16A 4gkhF-2i2xA:
undetectable		 4gkhF-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.14A 4gkhG-2i2xA:
undetectable		 4gkhG-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.15A 4gkhC-2i2xA:
undetectable
4gkhK-2i2xA:
undetectable		 4gkhC-2i2xA:
19.22
4gkhK-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.18A 4gkiA-2i2xA:
undetectable		 4gkiA-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.15A 4gkiC-2i2xA:
undetectable		 4gkiC-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASN A 224
GLU A 313
ASP A 219
GLU A 272
 None
K  A 511 (-3.6A)
None
None
 1.14A 4gkiE-2i2xA:
undetectable
4gkiG-2i2xA:
undetectable		 4gkiE-2i2xA:
19.22
4gkiG-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 VAL A 101
GLN A 105
TYR A  62
MET A  91
 None
 1.24A 4hxyB-2i2xA:
undetectable		 4hxyB-2i2xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 GLU A 316
THR A  85
LEU A  58
SER A 314
 None
None
None
B13  B 500 ( 3.8A)
 1.04A 4pfjA-2i2xA:
undetectable		 4pfjA-2i2xA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 11 ILE A  40
ALA A  36
ILE A 213
LEU A 160
ARG A 123
 None
 1.27A 4qi9C-2i2xA:
undetectable		 4qi9C-2i2xA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 5 GLY A 270
THR A 218
GLY A 266
GLU A 272
 None
ZN  A 501 ( 4.7A)
None
None
 0.96A 4v20A-2i2xA:
undetectable		 4v20A-2i2xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.42A 4w5qA-2i2xB:
5.6		 4w5qA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.38A 4w5rA-2i2xB:
5.7		 4w5rA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.39A 4w5tA-2i2xB:
5.6		 4w5tA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.41A 4z4cA-2i2xB:
5.7		 4z4cA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.42A 4z4fA-2i2xB:
5.5		 4z4fA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 5 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.41A 4z4gA-2i2xB:
5.2		 4z4gA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 6 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.43A 4z4iA-2i2xB:
5.7		 4z4iA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 ILE B  63
LEU B  72
TYR B 111
GLY B  58
 None
 0.89A 4z69A-2i2xB:
3.8		 4z69A-2i2xB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 SER A 162
MET A 340
GLU A 164
GLU A  84
THR A 218
 None
None
ZN  A 501 ( 2.3A)
None
ZN  A 501 ( 4.7A)
 1.30A 4zjoA-2i2xA:
0.0		 4zjoA-2i2xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 SER A 311
THR A 285
PHE A 146
GLU A 313
GLU A  86
 None
None
None
K  A 511 (-3.6A)
K  A 511 (-2.6A)
 1.35A 4zjqD-2i2xA:
0.3		 4zjqD-2i2xA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 5 THR A  18
GLY A  20
GLU A 345
ASP A 349
 None
 1.22A 5c0oH-2i2xA:
undetectable		 5c0oH-2i2xA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 10 ASP A 297
GLU A  84
GLU A 164
GLU A  86
GLU A  42
 None
None
ZN  A 501 ( 2.3A)
K  A 511 (-2.6A)
None
 1.50A 5iqgA-2i2xA:
0.0		 5iqgA-2i2xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 GLU A 450
LYS A 446
ASP A 180
GLY A 183
LEU A 191
 None
 1.16A 5kbwA-2i2xA:
2.5		 5kbwA-2i2xA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2i2x METHYLTRANSFERASE 1
METHYLTRANSFERASE 1
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 6 ARG B  15
ARG A 363
ALA A 367
PRO A 365
 None
 1.41A 5odqA-2i2xB:
6.2		 5odqA-2i2xB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 GLY A 157
LEU A 122
CYH A 120
ALA A  28
 None
 0.98A 5xu8A-2i2xA:
undetectable		 5xu8A-2i2xA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 12 PRO A 252
ILE A 245
VAL A 378
LEU A 422
MET A 369
 None
 1.11A 6b52A-2i2xA:
undetectable		 6b52A-2i2xA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		5 / 6 ALA A 221
SER A 187
GLY A 192
ILE A 199
PHE A 146
 B13  B 500 ( 3.8A)
None
None
None
None
 1.49A 6f8cA-2i2xA:
undetectable		 6f8cA-2i2xA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 8 ASP A 354
TYR A 372
GLY A 379
SER A 381
 None
 1.06A 6giqL-2i2xA:
undetectable
6giqP-2i2xA:
undetectable
6giqT-2i2xA:
undetectable		 6giqL-2i2xA:
21.81
6giqP-2i2xA:
18.64
6giqT-2i2xA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2i2x METHYLTRANSFERASE 1
METHYLTRANSFERASE 1
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 6 TYR A 368
ILE A 404
ALA A 409
ASP B   3
 None
 1.10A 6hu9m-2i2xA:
0.0
6hu9q-2i2xA:
0.0		 6hu9m-2i2xA:
20.72
6hu9q-2i2xA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2i2x METHYLTRANSFERASE 1
(Methanosarcina
barkeri) 		4 / 7 SER A 193
ALA A 393
ILE A 245
ALA A 246
 None
 0.83A 6ma7A-2i2xA:
undetectable		 6ma7A-2i2xA:
10.22