SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
(Homo
sapiens) 		3 / 3 ALA A  67
VAL A   4
TRP A 153
 None
 0.90A 1micA-2i32A:
undetectable
1micB-2i32A:
undetectable		 1micA-2i32A:
8.18
1micB-2i32A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A  68
PRO E 463
PHE A  28
ASN A   7
 None
 0.95A 1oniG-2i32A:
undetectable
1oniI-2i32A:
undetectable		 1oniG-2i32A:
22.63
1oniI-2i32A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
(Homo
sapiens) 		4 / 7 PHE A  74
VAL A  56
ASP A  58
ILE A  42
 None
 0.93A 1p7rA-2i32A:
undetectable		 1p7rA-2i32A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP A  77
GLU E 451
ARG E 458
 None
 0.83A 1wopA-2i32A:
undetectable		 1wopA-2i32A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
(Homo
sapiens) 		4 / 8 THR A 147
ILE A 151
ILE A  43
PHE A 106
 None
 0.87A 4r38D-2i32A:
undetectable		 4r38D-2i32A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
(Homo
sapiens) 		4 / 7 ASN A  80
PRO A  81
PHE A 132
PHE A  22
 None
 1.44A 4v32C-2i32A:
undetectable		 4v32C-2i32A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A
(Homo
sapiens;
Homo
sapiens) 		4 / 4 THR E 452
VAL E 450
PRO A  64
THR E 462
 None
 1.21A 5mthA-2i32E:
undetectable
5mthH-2i32E:
undetectable		 5mthA-2i32E:
18.54
5mthH-2i32E:
18.54