SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 6 VAL A 141
GLY A 142
ALA A 102
LEU A  71
 None
 0.81A 1e7bB-2i34A:
undetectable		 1e7bB-2i34A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 THR A 134
LEU A 138
VAL A 141
 None
 0.66A 1mz9E-2i34A:
undetectable		 1mz9E-2i34A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 10 GLY A 142
VAL A 141
LEU A  66
TYR A 122
ALA A 102
 None
None
WO4  A 401 (-4.1A)
None
None
 1.16A 1pbcA-2i34A:
undetectable		 1pbcA-2i34A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.90A 2aylA-2i34A:
undetectable		 2aylA-2i34A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 6 LEU A  66
TYR A 122
ILE A 151
GLY A 142
 WO4  A 401 (-4.1A)
None
None
None
 0.67A 2du8A-2i34A:
undetectable		 2du8A-2i34A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 6 LEU A  66
TYR A 122
ILE A 151
GLY A 142
 WO4  A 401 (-4.1A)
None
None
None
 0.67A 2du8B-2i34A:
undetectable		 2du8B-2i34A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 7 GLU A  68
TRP A  94
TRP A  91
LEU A  71
 None
 1.44A 2rezA-2i34A:
0.0		 2rezA-2i34A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 10 ILE A 174
PHE A 109
LEU A 103
THR A  69
GLY A  44
 None
 1.31A 2v0mA-2i34A:
undetectable		 2v0mA-2i34A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 6 ASP A 244
LEU A 246
ASP A 239
LEU A  16
 None
 1.16A 3bj8C-2i34A:
undetectable
3bj8D-2i34A:
undetectable		 3bj8C-2i34A:
21.74
3bj8D-2i34A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.93A 3nt1A-2i34A:
undetectable		 3nt1A-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.95A 3nt1B-2i34A:
undetectable		 3nt1B-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 ARG A 140
ILE A  95
TRP A  94
 None
 1.09A 3nw2A-2i34A:
undetectable		 3nw2A-2i34A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 ARG A 140
ILE A  95
TRP A  94
 None
 1.15A 3nw2B-2i34A:
undetectable		 3nw2B-2i34A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 8 ILE A 120
ILE A  62
PHE A 178
GLY A  44
 None
 0.70A 4ac9C-2i34A:
3.0		 4ac9C-2i34A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 8 ILE A 120
ILE A  62
PHE A 178
GLY A  44
 None
 0.76A 4acaC-2i34A:
3.1		 4acaC-2i34A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 8 ILE A 120
ILE A  62
PHE A 178
GLY A  44
 None
 0.72A 4acbC-2i34A:
2.9		 4acbC-2i34A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 8 GLU A 237
ASP A 244
ILE A 241
ASP A 228
 None
 0.83A 4kttD-2i34A:
undetectable		 4kttD-2i34A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 ASP A 184
ASP A 180
ASN A  73
 MG  A 301 ( 4.2A)
MG  A 301 (-2.5A)
None
 0.71A 4q5mA-2i34A:
undetectable		 4q5mA-2i34A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 PRO A 217
MET A 218
TYR A  27
 None
 1.07A 4qa0B-2i34A:
1.8		 4qa0B-2i34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 PRO A 217
MET A 218
TYR A  27
 None
 1.06A 4qa0A-2i34A:
1.5		 4qa0A-2i34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 4rrwA-2i34A:
undetectable		 4rrwA-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.99A 4rrwB-2i34A:
undetectable		 4rrwB-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 4rrwC-2i34A:
undetectable		 4rrwC-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.99A 4rrxA-2i34A:
undetectable		 4rrxA-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 1.01A 4rrxB-2i34A:
undetectable		 4rrxB-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 4rrzA-2i34A:
undetectable		 4rrzA-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.99A 4rrzB-2i34A:
undetectable		 4rrzB-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 4rrzC-2i34A:
undetectable		 4rrzC-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		3 / 3 GLU A 223
ARG A 242
GLN A  77
 None
 0.94A 4rtbA-2i34A:
undetectable		 4rtbA-2i34A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		4 / 6 ARG A 165
ASP A 189
LYS A 191
ARG A 196
 None
 1.48A 5a06A-2i34A:
undetectable		 5a06A-2i34A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.85A 5ikrA-2i34A:
undetectable		 5ikrA-2i34A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 5jvzA-2i34A:
undetectable		 5jvzA-2i34A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.96A 5jvzB-2i34A:
undetectable		 5jvzB-2i34A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 12 VAL A  70
ALA A  98
GLY A 142
ALA A 143
LEU A 110
 None
 1.08A 5kirA-2i34A:
undetectable		 5kirA-2i34A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 10 ILE A 120
LEU A  64
LEU A 103
ALA A 102
LEU A  71
 None
 1.04A 5y7pB-2i34A:
undetectable		 5y7pB-2i34A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 10 ILE A 120
LEU A  64
LEU A 103
ALA A 102
LEU A  71
 None
 1.03A 5y7pD-2i34A:
undetectable		 5y7pD-2i34A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2i34 ACID PHOSPHATASE
(Bacillus
anthracis) 		5 / 10 ILE A 120
LEU A  64
LEU A 103
ALA A 102
LEU A  71
 None
 1.07A 5y7pH-2i34A:
undetectable		 5y7pH-2i34A:
24.71