SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		5 / 11 ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
 None
 1.17A 1uduA-2i3bA:
undetectable		 1uduA-2i3bA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		5 / 12 ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
 None
 1.05A 1xozA-2i3bA:
undetectable		 1xozA-2i3bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		3 / 3 ILE A 111
ILE A 157
LEU A  25
 None
 0.44A 2prgA-2i3bA:
undetectable		 2prgA-2i3bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		4 / 5 ILE A 157
VAL A 154
PHE A 120
HIS A   3
 None
 1.24A 4rzvA-2i3bA:
undetectable		 4rzvA-2i3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		5 / 12 GLY A  34
THR A  57
ILE A 111
LEU A  90
LEU A  95
 None
 1.12A 5bw4A-2i3bA:
undetectable		 5bw4A-2i3bA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens) 		3 / 3 TYR A  36
ALA A  91
LEU A  90
 None
 0.61A 6ag0C-2i3bA:
undetectable		 6ag0C-2i3bA:
17.62