SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.20A 1d1gB-2i3oA:
undetectable		 1d1gB-2i3oA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ILE A 328
ARG A 370
ASN A 382
GLY A 414
ASP A 415
 None
 1.34A 1ho5A-2i3oA:
2.4		 1ho5A-2i3oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.28A 1j3jB-2i3oA:
undetectable		 1j3jB-2i3oA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 112
LEU A  75
GLY A  56
GLY A  59
ASN A 350
 None
 1.16A 1likA-2i3oA:
undetectable		 1likA-2i3oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.22A 1rb3A-2i3oA:
undetectable		 1rb3A-2i3oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 347
GLN A 348
GLY A  77
GLY A 111
LEU A  75
 None
 1.10A 1rjdA-2i3oA:
undetectable		 1rjdA-2i3oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 347
GLN A 348
GLY A  77
GLY A 111
LEU A  75
 None
 1.09A 1rjdB-2i3oA:
undetectable		 1rjdB-2i3oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 PHE A  62
ILE A 119
ILE A 112
SER A 345
PHE A 123
 None
 1.20A 1sg9A-2i3oA:
undetectable		 1sg9A-2i3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A 410
SER A 345
VAL A 420
ALA A 489
ASP A 505
 None
 1.45A 2avdA-2i3oA:
undetectable		 2avdA-2i3oA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ASN A 254
TYR A 204
GLY A 111
ASP A  60
THR A 108
 None
 1.41A 2f9wA-2i3oA:
undetectable
2f9wB-2i3oA:
undetectable		 2f9wA-2i3oA:
19.35
2f9wB-2i3oA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 LEU A 183
SER A 156
VAL A 359
GLY A 165
 None
 1.11A 2qd5A-2i3oA:
undetectable		 2qd5A-2i3oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 LEU A 183
SER A 156
VAL A 359
GLY A 165
 None
 1.11A 2qd5B-2i3oA:
undetectable		 2qd5B-2i3oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 119
ILE A 112
LEU A  57
CYH A  48
PHE A 192
 None
 1.14A 2qo5A-2i3oA:
undetectable		 2qo5A-2i3oA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 LEU A 223
ILE A 213
LEU A 216
ALA A 106
THR A 363
 None
 1.19A 2qo6A-2i3oA:
2.1		 2qo6A-2i3oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 PRO A 454
ARG A 296
ARG A 297
ASP A 294
 None
 1.30A 2rhmD-2i3oA:
undetectable		 2rhmD-2i3oA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 PHE A  62
ARG A 370
THR A 390
ILE A 212
GLY A  77
 None
 1.35A 2v0mA-2i3oA:
0.4		 2v0mA-2i3oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 VAL A 230
ASP A 301
LEU A 384
ARG A 226
 None
 0.96A 2ziaA-2i3oA:
undetectable		 2ziaA-2i3oA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ALA A 395
LEU A 394
ARG A 370
PHE A 391
GLY A 414
 None
 1.16A 3bpxA-2i3oA:
undetectable
3bpxB-2i3oA:
undetectable		 3bpxA-2i3oA:
13.89
3bpxB-2i3oA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A 371
ASN A 369
TYR A 351
ARG A 370
 None
 1.35A 3ccfA-2i3oA:
undetectable		 3ccfA-2i3oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.23A 3clbD-2i3oA:
undetectable		 3clbD-2i3oA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ASP A 509
ASP A 505
ASP A 151
 None
 0.77A 3douA-2i3oA:
undetectable		 3douA-2i3oA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 TYR A 104
TYR A 163
ILE A 358
 None
 0.85A 3eteA-2i3oA:
undetectable
3eteB-2i3oA:
undetectable		 3eteA-2i3oA:
21.98
3eteB-2i3oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ASP A 330
LEU A  54
GLN A 490
 None
 0.72A 3g4lA-2i3oA:
undetectable		 3g4lA-2i3oA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.24A 3hbbD-2i3oA:
undetectable		 3hbbD-2i3oA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ASP A 338
PHE A  37
SER A 335
 None
 0.98A 3i5uB-2i3oA:
undetectable		 3i5uB-2i3oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A   5
ILE A 424
THR A 445
 None
 0.58A 3ia4D-2i3oA:
undetectable		 3ia4D-2i3oA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ASN A 254
ASP A  60
ARG A 226
 None
 0.89A 3k13C-2i3oA:
undetectable		 3k13C-2i3oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.31A 3qgtA-2i3oA:
undetectable		 3qgtA-2i3oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.25A 3qgtB-2i3oA:
undetectable		 3qgtB-2i3oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.18A 3ql3A-2i3oA:
undetectable		 3ql3A-2i3oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 8 GLY A  26
ALA A  25
ASP A  28
ILE A 511
THR A  50
 None
 1.17A 3so9A-2i3oA:
undetectable		 3so9A-2i3oA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ALA A 124
ASP A  38
ILE A 346
ILE A  65
THR A 125
 None
 1.18A 3tq8A-2i3oA:
undetectable		 3tq8A-2i3oA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 GLN A 185
PHE A 143
TYR A 149
 None
 0.99A 3ucjB-2i3oA:
undetectable		 3ucjB-2i3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 GLN A 185
PHE A 143
TYR A 149
 None
 0.98A 3ucjA-2i3oA:
undetectable		 3ucjA-2i3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ASP A 434
GLY A 502
THR A 492
ILE A 491
 None
 0.94A 4acaC-2i3oA:
undetectable		 4acaC-2i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 TYR A 406
THR A 433
VAL A 501
ILE A 428
 None
 1.48A 4jx1F-2i3oA:
undetectable		 4jx1F-2i3oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A  36
ALA A  39
ALA A  40
LEU A  30
VAL A 500
 None
 1.01A 4k6iA-2i3oA:
undetectable		 4k6iA-2i3oA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 LEU A 409
SER A 411
LEU A 439
LEU A 425
 None
 1.31A 4n09D-2i3oA:
undetectable		 4n09D-2i3oA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 LEU A  47
GLY A  26
ALA A  25
ASP A  28
ILE A 511
 None
 1.13A 4njtD-2i3oA:
undetectable		 4njtD-2i3oA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  79
ILE A 112
GLY A  58
ARG A 201
PHE A 203
 None
 1.08A 4obwC-2i3oA:
undetectable		 4obwC-2i3oA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  79
ILE A 112
GLY A  58
ARG A 201
PHE A 203
 None
 1.10A 4obwD-2i3oA:
undetectable		 4obwD-2i3oA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 GLU A 250
THR A 251
LEU A  64
GLN A 421
 None
 1.29A 4qztA-2i3oA:
undetectable		 4qztA-2i3oA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 LEU A  30
ALA A  42
VAL A 344
ILE A 346
 None
 0.91A 4xe3A-2i3oA:
undetectable		 4xe3A-2i3oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 TYR A 149
THR A 146
GLY A 508
THR A 488
LEU A  54
 None
 1.28A 4ze0A-2i3oA:
undetectable		 4ze0A-2i3oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ILE A 428
LEU A 409
ILE A 438
ARG A 443
 None
 0.77A 4zvcA-2i3oA:
0.0
4zvcB-2i3oA:
0.1		 4zvcA-2i3oA:
14.60
4zvcB-2i3oA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ILE A 438
ARG A 443
ILE A 428
LEU A 409
 None
 0.78A 4zvcA-2i3oA:
0.0
4zvcB-2i3oA:
0.1		 4zvcA-2i3oA:
14.60
4zvcB-2i3oA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 PHE A 486
ALA A 489
GLY A 487
GLY A 413
 None
 0.76A 5ybbB-2i3oA:
undetectable		 5ybbB-2i3oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 ALA A 113
SER A 115
GLY A  77
TYR A 231
 None
 1.06A 5yodB-2i3oA:
undetectable		 5yodB-2i3oA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 ALA A 113
SER A 115
GLY A  77
TYR A 231
 None
 1.18A 5yodD-2i3oA:
undetectable		 5yodD-2i3oA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 VAL A 239
ILE A 258
GLU A 262
ARG A 265
 None
 0.98A 5z3jA-2i3oA:
undetectable		 5z3jA-2i3oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ALA A  16
ILE A 438
LEU A 439
ILE A 495
 None
 0.83A 6b5vA-2i3oA:
undetectable
6b5vB-2i3oA:
undetectable		 6b5vA-2i3oA:
10.41
6b5vB-2i3oA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 GLY A 341
ASP A 498
ILE A 495
 None
 0.61A 6dgxB-2i3oA:
undetectable		 6dgxB-2i3oA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 GLY A  56
LEU A 188
ALA A 139
ALA A 135
PHE A 192
 None
 1.18A 6qgbA-2i3oA:
undetectable		 6qgbA-2i3oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 GLY A  56
LEU A 188
ALA A 139
ALA A 135
PHE A 192
 None
 1.16A 6qgbE-2i3oA:
undetectable		 6qgbE-2i3oA:
23.85