SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		3 / 3 PHE A 132
ASN A  83
PHE A 128
 None
 1.02A 2zbuD-2i3yA:
undetectable		 2zbuD-2i3yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		5 / 12 PHE A  56
GLY A 192
PHE A 186
VAL A  60
THR A  39
 None
 0.88A 3dh0B-2i3yA:
undetectable		 3dh0B-2i3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		3 / 3 ASN A 112
LEU A 119
PHE A 135
 None
 0.71A 4dajB-2i3yA:
undetectable		 4dajB-2i3yA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		4 / 6 VAL A 140
ARG A 197
VAL A 148
PHE A 186
 None
 1.35A 5addA-2i3yA:
undetectable
5addB-2i3yA:
undetectable		 5addA-2i3yA:
20.14
5addB-2i3yA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		4 / 6 VAL A 140
ARG A 197
VAL A 148
PHE A 186
 None
 1.45A 5adeA-2i3yA:
undetectable
5adeB-2i3yA:
undetectable		 5adeA-2i3yA:
20.14
5adeB-2i3yA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		3 / 3 ASN A 112
LEU A 119
PHE A 135
 None
 0.75A 5dsgA-2i3yA:
undetectable		 5dsgA-2i3yA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE
(Homo
sapiens) 		3 / 3 GLU A 184
TRP A 181
ASN A 141
 None
EDO  A 221 ( 3.7A)
None
 0.88A 5dv4A-2i3yA:
undetectable		 5dv4A-2i3yA:
19.19