SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 5 PHE A  66
GLY A  64
THR A  16
PHE A  62
 None
 1.36A 1icuC-2i44A:
undetectable
1icuD-2i44A:
0.6		 1icuC-2i44A:
23.53
1icuD-2i44A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 5 PHE A  66
GLY A  64
THR A  16
PHE A  62
 None
 1.29A 1icvA-2i44A:
undetectable
1icvB-2i44A:
undetectable		 1icvA-2i44A:
23.53
1icvB-2i44A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.89A 1jnoA-2i44A:
undetectable		 1jnoA-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.89A 1jnoB-2i44A:
undetectable		 1jnoB-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.92A 1jo3A-2i44A:
undetectable		 1jo3A-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.92A 1jo3B-2i44A:
undetectable		 1jo3B-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.90A 1magA-2i44A:
undetectable		 1magA-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.90A 1magB-2i44A:
undetectable		 1magB-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.91A 1ng8A-2i44A:
undetectable		 1ng8A-2i44A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 ALA A  61
VAL A  54
TRP A  92
 None
 0.90A 1ng8B-2i44A:
undetectable		 1ng8B-2i44A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 THR A 306
ALA A 299
GLY A 274
THR A 272
ALA A 271
 None
None
CA  A 401 ( 4.8A)
None
None
 0.99A 2f16H-2i44A:
4.0
2f16I-2i44A:
3.1		 2f16H-2i44A:
20.97
2f16I-2i44A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 THR A 306
ALA A 299
GLY A 274
THR A 272
ALA A 271
 None
None
CA  A 401 ( 4.8A)
None
None
 1.00A 2f16V-2i44A:
3.5
2f16W-2i44A:
3.4		 2f16V-2i44A:
20.97
2f16W-2i44A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		3 / 3 SER A 145
THR A  35
GLN A  43
 None
 0.66A 2fk8A-2i44A:
undetectable		 2fk8A-2i44A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 ALA A 127
ASP A 128
GLU A 130
LEU A 131
GLY A  64
 None
 1.11A 2jfaB-2i44A:
undetectable		 2jfaB-2i44A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 LEU A  86
ALA A 119
LEU A 116
ALA A 153
VAL A  54
 None
 1.18A 3e22B-2i44A:
undetectable		 3e22B-2i44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 LEU A  86
ALA A 119
LEU A 116
ALA A 153
VAL A  54
 None
 1.20A 3e22D-2i44A:
undetectable		 3e22D-2i44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 8 TYR A 124
VAL A  83
ILE A 167
GLY A  64
 None
 0.94A 3hjoA-2i44A:
undetectable		 3hjoA-2i44A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 4 GLY A 201
TYR A 248
GLY A 218
ASP A 220
 None
 1.33A 3kl3A-2i44A:
undetectable		 3kl3A-2i44A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 ARG A 296
VAL A 278
ALA A 301
LEU A 307
ILE A 320
 None
 1.04A 3ku1H-2i44A:
undetectable		 3ku1H-2i44A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 TYR A 236
VAL A 148
SER A 165
SER A 145
VAL A  82
 None
 1.30A 3m7rA-2i44A:
undetectable		 3m7rA-2i44A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 THR A 306
ALA A 299
GLY A 274
THR A 272
ALA A 271
 None
None
CA  A 401 ( 4.8A)
None
None
 1.00A 3mg0V-2i44A:
3.7
3mg0W-2i44A:
3.4		 3mg0V-2i44A:
20.97
3mg0W-2i44A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 5 ARG A  40
ASP A  67
ASP A 273
ASP A 164
 None
CA  A 401 ( 2.4A)
CA  A 401 (-2.8A)
None
 1.46A 3naiC-2i44A:
0.0		 3naiC-2i44A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 ASP A  80
ALA A  74
LEU A  53
PHE A  62
THR A  48
 None
 1.35A 4iarA-2i44A:
undetectable		 4iarA-2i44A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 8 LEU A  53
VAL A  83
LEU A 112
LEU A 116
 None
 0.88A 4l1xA-2i44A:
undetectable		 4l1xA-2i44A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 6 ASP A 185
ARG A 166
GLY A 274
VAL A 278
 None
None
CA  A 401 ( 4.8A)
None
 0.94A 4oltA-2i44A:
undetectable		 4oltA-2i44A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 4 ASN A 297
VAL A 303
THR A 324
ILE A 269
 None
 1.34A 4retA-2i44A:
undetectable		 4retA-2i44A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 4 ASN A 297
VAL A 303
THR A 324
ILE A 269
 None
 1.34A 4retC-2i44A:
undetectable		 4retC-2i44A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 8 HIS A 186
ASP A 185
SER A 165
ARG A 166
 None
 1.22A 4uhxA-2i44A:
undetectable		 4uhxA-2i44A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 8 HIS A 186
ASP A 185
SER A 165
ARG A 166
 None
 1.22A 4uhxA-2i44A:
undetectable		 4uhxA-2i44A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 LEU A  86
ALA A 119
LEU A 116
ALA A 153
VAL A  54
 None
 1.26A 4x1iB-2i44A:
undetectable		 4x1iB-2i44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 ASP A 164
GLY A 163
ILE A 216
PRO A 214
VAL A 204
 None
 0.87A 4xdrA-2i44A:
1.1		 4xdrA-2i44A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 10 GLY A 242
TYR A 142
ILE A 216
LEU A 245
LEU A 250
 None
 1.23A 4xj7A-2i44A:
undetectable
4xj7B-2i44A:
undetectable		 4xj7A-2i44A:
21.26
4xj7B-2i44A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		4 / 5 CYH A  50
GLN A  52
PRO A  14
ILE A  87
 None
 1.43A 5ki6A-2i44A:
undetectable		 5ki6A-2i44A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 LEU A 162
GLY A 163
HIS A 161
VAL A 204
ASP A 189
 None
 1.43A 6bxnB-2i44A:
undetectable		 6bxnB-2i44A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 12 THR A 306
ALA A 299
GLY A 274
THR A 272
ALA A 271
 None
None
CA  A 401 ( 4.8A)
None
None
 1.03A 6hwdH-2i44A:
3.5
6hwdI-2i44A:
undetectable		 6hwdH-2i44A:
15.30
6hwdI-2i44A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2i44 SERINE-THREONINE
PHOSPHATASE 2C
(Toxoplasma
gondii) 		5 / 11 THR A 306
ALA A 299
GLY A 274
THR A 272
ALA A 271
 None
None
CA  A 401 ( 4.8A)
None
None
 1.03A 6hwdV-2i44A:
3.8		 6hwdV-2i44A:
15.30