SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A 380
ILE A 377
PRO A 123
ILE A 132
 None
 0.84A 1n49D-2i4cA:
undetectable		 1n49D-2i4cA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASN A 166
ILE A 217
VAL A 156
ALA A 155
PHE A 206
 None
 1.29A 1udtA-2i4cA:
undetectable		 1udtA-2i4cA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 173
VAL A 165
TRP A 205
 None
 0.85A 1w5uC-2i4cA:
undetectable
1w5uD-2i4cA:
undetectable		 1w5uC-2i4cA:
4.14
1w5uD-2i4cA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 153
GLY A 151
GLU A  70
GLN A 198
ILE A 202
 None
None
CA  A 461 ( 3.3A)
CA  A 461 ( 3.0A)
None
 1.35A 2akeA-2i4cA:
undetectable		 2akeA-2i4cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 209
TYR A 175
ALA A 208
ASP A 431
TYR A 204
 None
 1.21A 2avdA-2i4cA:
undetectable		 2avdA-2i4cA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 153
GLY A 151
GLU A  70
GLN A 198
ILE A 202
 None
None
CA  A 461 ( 3.3A)
CA  A 461 ( 3.0A)
None
 1.35A 2azxA-2i4cA:
undetectable		 2azxA-2i4cA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 153
GLY A 151
GLU A  70
GLN A 198
ILE A 202
 None
None
CA  A 461 ( 3.3A)
CA  A 461 ( 3.0A)
None
 1.34A 2azxB-2i4cA:
undetectable		 2azxB-2i4cA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A 153
GLY A 151
GLU A  70
GLN A 198
ILE A 202
 None
None
CA  A 461 ( 3.3A)
CA  A 461 ( 3.0A)
None
 1.33A 2dr2A-2i4cA:
undetectable		 2dr2A-2i4cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 9 ILE A 249
ARG A 248
ALA A 225
VAL A 228
 None
 0.95A 2vufB-2i4cA:
undetectable		 2vufB-2i4cA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 11 SER A 423
LEU A 389
SER A 367
LEU A 370
LEU A 444
 None
 1.09A 2xn5A-2i4cA:
undetectable		 2xn5A-2i4cA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 115
ALA A  71
GLY A 118
LEU A 327
PHE A 320
 None
 1.07A 2y7hB-2i4cA:
undetectable		 2y7hB-2i4cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 115
ALA A  71
GLY A 118
LEU A 327
PHE A 320
 None
 1.07A 2y7hC-2i4cA:
undetectable		 2y7hC-2i4cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 297
PRO A  73
ILE A  76
GLU A 309
 None
 0.73A 3dtuC-2i4cA:
undetectable
3dtuD-2i4cA:
undetectable		 3dtuC-2i4cA:
21.64
3dtuD-2i4cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 173
VAL A 165
TRP A 205
 None
 0.82A 3l8lC-2i4cA:
undetectable
3l8lD-2i4cA:
undetectable		 3l8lC-2i4cA:
4.14
3l8lD-2i4cA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 VAL A  93
LEU A  63
ILE A 294
ALA A  77
 None
 0.97A 3n8yB-2i4cA:
undetectable		 3n8yB-2i4cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 435
THR A 428
GLY A 425
SER A 367
 None
 1.10A 3tzfB-2i4cA:
undetectable		 3tzfB-2i4cA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 ILE A 115
GLN A  96
ILE A  66
GLU A 271
 None
None
None
BCT  A 460 ( 2.9A)
 1.15A 4a99D-2i4cA:
undetectable		 4a99D-2i4cA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 4 ALA A 277
VAL A 280
ASP A 281
LEU A 404
 None
 0.94A 4e7gA-2i4cA:
undetectable		 4e7gA-2i4cA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A 298
GLY A 293
ALA A 289
PHE A  83
LEU A  63
 None
 1.21A 4hytA-2i4cA:
undetectable		 4hytA-2i4cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A 298
GLY A 293
ALA A 289
PHE A  83
LEU A  63
 None
 1.25A 4retA-2i4cA:
undetectable		 4retA-2i4cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A 298
GLY A 293
ALA A 289
PHE A  83
LEU A  63
 None
 1.25A 4retC-2i4cA:
undetectable		 4retC-2i4cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 10 SER A 423
LEU A 389
SER A 367
LEU A 370
LEU A 444
 None
 1.04A 4yiaA-2i4cA:
undetectable		 4yiaA-2i4cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 7 PRO A 224
ILE A  68
ILE A  66
THR A 192
 None
BCT  A 460 (-4.5A)
None
BCT  A 460 (-2.7A)
 0.91A 5murB-2i4cA:
undetectable		 5murB-2i4cA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 172
VAL A 165
TYR A 175
ALA A 208
TYR A 204
 None
 1.16A 5n5dB-2i4cA:
undetectable		 5n5dB-2i4cA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		3 / 3 TRP A 120
MET A 122
ASN A 197
 None
 0.83A 5uc1B-2i4cA:
undetectable		 5uc1B-2i4cA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		3 / 3 TRP A 120
MET A 122
ASN A 197
 None
 0.83A 5uc1A-2i4cA:
undetectable		 5uc1A-2i4cA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 8 PRO A 246
ALA A 238
THR A 241
ALA A 262
 None
 0.98A 5x2tI-2i4cA:
undetectable
5x2tJ-2i4cA:
undetectable
5x2tK-2i4cA:
undetectable
5x2tL-2i4cA:
undetectable		 5x2tI-2i4cA:
15.38
5x2tJ-2i4cA:
16.32
5x2tK-2i4cA:
15.38
5x2tL-2i4cA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 6 SER A  94
ALA A  97
ALA A 102
SER A 101
 None
 1.03A 6bocA-2i4cA:
undetectable
6bocB-2i4cA:
undetectable
6bocC-2i4cA:
undetectable
6bocD-2i4cA:
undetectable		 6bocA-2i4cA:
4.98
6bocB-2i4cA:
4.98
6bocC-2i4cA:
4.98
6bocD-2i4cA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2i4c BICARBONATE
TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A 357
GLY A 359
ASP A 356
LEU A 352
VAL A 361
 None
 1.28A 6i5zD-2i4cA:
undetectable		 6i5zD-2i4cA:
23.09