SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 VAL A 318
LEU A 323
MET A 188
VAL A 343
 None
 0.99A 1fduB-2i4nA:
undetectable		 1fduB-2i4nA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 433
LEU A 437
LEU A 417
ILE A 350
LEU A 351
 None
 0.88A 1mx1D-2i4nA:
undetectable		 1mx1D-2i4nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 ALA A 299
ARG A 119
TYR A 293
PHE A 163
 None
 1.07A 2ajvH-2i4nA:
undetectable
2ajvL-2i4nA:
undetectable		 2ajvH-2i4nA:
17.66
2ajvL-2i4nA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 LYS A 172
SER A 173
SER A 162
ASP A 166
 None
 1.15A 2obvA-2i4nA:
undetectable		 2obvA-2i4nA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 8 ALA A  41
GLU A  35
LEU A  32
LEU A  27
ILE A  10
 None
 1.45A 2uxpA-2i4nA:
undetectable		 2uxpA-2i4nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 217
THR A 278
GLU A 218
ALA A 214
 None
 0.78A 3fpjB-2i4nA:
undetectable		 3fpjB-2i4nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 159
GLU A 112
SER A 321
 None
None
5CA  A 439 ( 4.3A)
 0.82A 3p2kA-2i4nA:
undetectable		 3p2kA-2i4nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 9 LEU A 396
GLY A  46
PRO A   9
ILE A  10
ILE A 397
 None
 1.05A 3s56B-2i4nA:
undetectable		 3s56B-2i4nA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 LEU A 190
GLY A 280
GLU A 218
ALA A 214
 None
 1.00A 3tehB-2i4nA:
11.7		 3tehB-2i4nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		3 / 3 TYR A  89
THR A 109
GLU A 142
 None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.2A)
 0.67A 4df3A-2i4nA:
undetectable		 4df3A-2i4nA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		3 / 3 TYR A  89
THR A 109
GLU A 142
 None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.2A)
 0.66A 4df3B-2i4nA:
undetectable		 4df3B-2i4nA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 GLU A 370
TYR A 368
ARG A   2
ARG A 369
 None
 0.96A 4fgzA-2i4nA:
undetectable
4fgzB-2i4nA:
undetectable		 4fgzA-2i4nA:
18.28
4fgzB-2i4nA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 5 ALA A 160
ILE A  67
LEU A  69
ASN A 131
 None
 1.22A 4g19A-2i4nA:
undetectable		 4g19A-2i4nA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.25A 4hvcB-2i4nA:
28.8		 4hvcB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 ARG A 140
ARG A 151
PHE A 155
GLY A 284
 5CA  A 439 (-2.8A)
None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.3A)
 0.80A 4k87A-2i4nA:
28.7		 4k87A-2i4nA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 ARG A 140
PHE A 155
GLY A 284
ARG A 322
 5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.3A)
5CA  A 439 (-3.7A)
 0.63A 4k87A-2i4nA:
28.7		 4k87A-2i4nA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
THR A 109
GLU A 111
ARG A 140
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-2.8A)
 0.57A 4k88A-2i4nA:
28.1		 4k88A-2i4nA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 108
THR A 109
GLU A 111
ARG A 140
SER A 315
 None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
 0.51A 4k88A-2i4nA:
28.1		 4k88A-2i4nA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 128
PRO A 129
LEU A 130
ILE A 122
 None
 1.07A 4klrA-2i4nA:
undetectable		 4klrA-2i4nA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 396
ILE A  10
LEU A  11
ARG A  28
 None
 0.83A 4mghA-2i4nA:
undetectable		 4mghA-2i4nA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 317
THR A  73
LEU A 156
GLY A 319
VAL A 320
 5CA  A 439 (-3.5A)
None
None
5CA  A 439 (-3.5A)
None
 0.93A 4o33A-2i4nA:
undetectable		 4o33A-2i4nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 317
THR A  73
LEU A 156
GLY A 319
VAL A 320
 5CA  A 439 (-3.5A)
None
None
5CA  A 439 (-3.5A)
None
 0.91A 4o3fA-2i4nA:
undetectable		 4o3fA-2i4nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 LEU A  11
LEU A  43
ILE A 337
ILE A 397
 None
 0.87A 4ojbA-2i4nA:
undetectable		 4ojbA-2i4nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 395
LYS A 390
LEU A 353
 None
 1.06A 4ptjA-2i4nA:
undetectable		 4ptjA-2i4nA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		7 / 12 LEU A 105
GLU A  92
PRO A 108
THR A 109
ARG A 140
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.11A 4q15A-2i4nA:
29.5		 4q15A-2i4nA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		7 / 12 LEU A 105
GLU A  92
PRO A 108
THR A 109
ARG A 140
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.13A 4q15B-2i4nA:
29.6		 4q15B-2i4nA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		6 / 12 LEU A 105
GLU A  92
PRO A 108
ARG A 140
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.06A 4ydqA-2i4nA:
28.4		 4ydqA-2i4nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		6 / 12 GLU A  92
PRO A 108
THR A 109
ARG A 140
SER A 315
GLY A 317
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 0.42A 4ydqB-2i4nA:
17.1		 4ydqB-2i4nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A 142
THR A 109
ARG A 140
SER A 315
GLY A 317
 5CA  A 439 (-3.2A)
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.42A 4ydqB-2i4nA:
17.1		 4ydqB-2i4nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		3 / 3 ARG A  58
LYS A  51
GLU A  54
 None
 0.79A 5d0yA-2i4nA:
undetectable		 5d0yA-2i4nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
ARG A 140
SER A 315
GLY A 317
 None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 0.40A 5f9zA-2i4nA:
28.0		 5f9zA-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
ARG A 140
GLY A 317
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.5A)
 1.12A 5f9zA-2i4nA:
28.0		 5f9zA-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
GLU A 111
GLY A 203
 None
None
None
5CA  A 439 (-2.6A)
None
 1.31A 5f9zA-2i4nA:
28.0		 5f9zA-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLY A  90
GLU A  92
GLU A 111
GLY A 203
 None
None
None
5CA  A 439 (-2.6A)
None
 1.34A 5f9zA-2i4nA:
28.0		 5f9zA-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
ARG A 140
SER A 315
GLY A 317
 None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 0.47A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
ARG A 140
GLY A 317
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.5A)
 1.12A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
GLU A 111
GLY A 203
 None
None
None
5CA  A 439 (-2.6A)
None
 1.33A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 9 LEU A 182
ILE A 246
ILE A 286
GLU A 209
VAL A 283
 None
None
None
None
5CA  A 439 (-4.5A)
 1.42A 5igzA-2i4nA:
undetectable		 5igzA-2i4nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 ARG A  24
LYS A  16
VAL A  49
GLY A 325
ILE A 328
 None
 1.21A 5vooA-2i4nA:
undetectable		 5vooA-2i4nA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		7 / 12 LEU A 105
GLU A  92
PRO A 108
THR A 109
ARG A 140
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.08A 5xipA-2i4nA:
28.2		 5xipA-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
THR A 109
GLU A 111
ARG A 140
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-2.8A)
 0.48A 5xipB-2i4nA:
27.9		 5xipB-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
THR A 109
GLU A 111
GLY A 317
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-3.5A)
 0.47A 5xipC-2i4nA:
28.3		 5xipC-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
THR A 109
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.17A 5xipC-2i4nA:
28.3		 5xipC-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
THR A 109
GLU A 111
ARG A 140
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-2.8A)
 0.42A 5xipD-2i4nA:
28.7		 5xipD-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
SER A 315
GLY A 317
 None
None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 1.27A 5xiqA-2i4nA:
28.8		 5xiqA-2i4nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
ARG A 140
SER A 315
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
 1.19A 5xiqB-2i4nA:
28.3		 5xiqB-2i4nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  92
PRO A 108
THR A 109
ARG A 140
SER A 315
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
 0.41A 5xiqC-2i4nA:
28.5		 5xiqC-2i4nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
ARG A 140
GLY A 317
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.5A)
 1.02A 5xiqD-2i4nA:
28.7		 5xiqD-2i4nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 GLU A  92
ARG A  95
PRO A 108
PRO A 201
 None
 1.33A 6a4iB-2i4nA:
undetectable		 6a4iB-2i4nA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		6 / 10 ARG A 140
GLU A 142
PHE A 155
GLU A 282
GLY A 319
ARG A 322
 5CA  A 439 (-2.8A)
5CA  A 439 (-3.2A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.7A)
5CA  A 439 (-3.5A)
5CA  A 439 (-3.7A)
 0.70A 6bniA-2i4nA:
9.4		 6bniA-2i4nA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		6 / 10 ARG A 140
GLU A 142
PHE A 155
GLU A 282
GLY A 319
ARG A 322
 5CA  A 439 (-2.8A)
5CA  A 439 (-3.2A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.7A)
5CA  A 439 (-3.5A)
5CA  A 439 (-3.7A)
 0.73A 6bniB-2i4nA:
11.5		 6bniB-2i4nA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 5 GLY A 423
ASP A 422
ARG A 420
ARG A 419
 None
 1.33A 6dwdB-2i4nA:
undetectable
6dwdD-2i4nA:
undetectable		 6dwdB-2i4nA:
24.28
6dwdD-2i4nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 5 ARG A 420
ARG A 419
GLY A 423
ASP A 422
 None
 1.39A 6dwjB-2i4nA:
0.9
6dwjD-2i4nA:
undetectable		 6dwjB-2i4nA:
24.28
6dwjD-2i4nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 6 THR A 109
ARG A 140
ARG A  85
ILE A 202
 5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
None
5CA  A 439 (-4.2A)
 1.25A 6ef6A-2i4nA:
0.9		 6ef6A-2i4nA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 6 ASP A 308
LEU A 128
SER A 127
PHE A 118
 None
 0.99A 6ekuA-2i4nA:
undetectable		 6ekuA-2i4nA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		4 / 8 LYS A 172
SER A 173
SER A 162
ASP A 166
 None
 1.21A 6fcdA-2i4nA:
undetectable		 6fcdA-2i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 105
GLU A  92
PRO A 108
GLU A 111
GLY A 203
 None
None
None
5CA  A 439 (-2.6A)
None
 1.41A 6mn8A-2i4nA:
32.9		 6mn8A-2i4nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2i4n PROLINE-TRNA LIGASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 360
GLY A 413
GLY A 409
VAL A 405
GLU A 412
 None
 1.27A 6nqaK-2i4nA:
undetectable		 6nqaK-2i4nA:
22.94