SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		5 / 9 ALA A 213
PHE A 305
SER A 252
ILE A 253
ILE A 221
 None
 1.30A 1j3jB-2i4sA:
undetectable		 1j3jB-2i4sA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		5 / 11 ALA A 213
PHE A 305
SER A 252
ILE A 253
ILE A 221
 None
 1.22A 2blaA-2i4sA:
undetectable		 2blaA-2i4sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 6 TYR A 239
MET A 275
ASN A 273
ASP A 271
 None
 1.31A 3lslG-2i4sA:
undetectable		 3lslG-2i4sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 7 ARG A 211
LEU A 249
GLU A 220
ILE A 214
 None
 0.89A 3s56B-2i4sA:
undetectable		 3s56B-2i4sA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		5 / 9 ILE A 253
GLN A 256
LEU A 255
VAL A 241
LEU A 290
 None
 1.17A 4g1bC-2i4sA:
undetectable		 4g1bC-2i4sA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 SER A 289
ALA A 263
VAL A 262
 None
 0.62A 4o2bC-2i4sA:
undetectable		 4o2bC-2i4sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 GLN A 297
HIS A 299
ARG A 294
 None
 1.18A 4qyqA-2i4sA:
undetectable		 4qyqA-2i4sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 GLN A 297
HIS A 299
ARG A 294
 None
 1.13A 4qyqB-2i4sA:
undetectable		 4qyqB-2i4sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 SER A 289
ALA A 263
VAL A 262
 None
 0.59A 4x1iA-2i4sA:
undetectable		 4x1iA-2i4sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		4 / 4 LEU A 269
MET A 275
VAL A 274
ASN A 273
 None
 1.41A 5b8iB-2i4sA:
undetectable		 5b8iB-2i4sA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2i4s GENERAL SECRETION
PATHWAY PROTEIN C
(Vibrio
cholerae) 		3 / 3 SER A 289
ALA A 263
VAL A 262
 None
 0.55A 5xiwC-2i4sA:
undetectable		 5xiwC-2i4sA:
18.27