SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 CYH A   7
ARG A   8
CYH A 102
 ZN  A 338 (-2.3A)
None
ZN  A 338 (-2.2A)
 1.32A 1p9gA-2i50A:
undetectable		 1p9gA-2i50A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		4 / 4 GLY A  66
SER A  53
VAL A  89
LEU A  75
 None
 1.33A 1yajB-2i50A:
undetectable		 1yajB-2i50A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 ASP A  37
THR A  80
PRO A  81
 None
 0.60A 2pynB-2i50A:
undetectable		 2pynB-2i50A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 ASP A  37
THR A  80
PRO A  81
 None
 0.63A 2q64B-2i50A:
undetectable		 2q64B-2i50A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 ASP A  37
THR A  80
PRO A  81
 None
 0.57A 2qakB-2i50A:
undetectable		 2qakB-2i50A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 THR A  80
ASP A  33
GLU A  71
 None
 0.75A 3qowA-2i50A:
undetectable		 3qowA-2i50A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16
(Homo
sapiens) 		3 / 3 THR A  80
ASP A  33
GLU A  71
 None
 0.65A 5fa8A-2i50A:
undetectable		 5fa8A-2i50A:
22.47