SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 2tsrA-2i53A:
undetectable		 2tsrA-2i53A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 8 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.91A 2tsrB-2i53A:
undetectable		 2tsrB-2i53A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 8 THR A  45
TYR A  82
ARG A  48
MET A 265
 None
None
ACT  A 301 (-2.9A)
None
 1.47A 3wipD-2i53A:
undetectable
3wipE-2i53A:
undetectable		 3wipD-2i53A:
18.52
3wipE-2i53A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2i53 CYCLIN K
(Homo
sapiens) 		3 / 3 LYS A 112
LYS A 111
PRO A 110
 None
 1.05A 4dv1L-2i53A:
undetectable		 4dv1L-2i53A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.89A 4iqqA-2i53A:
undetectable		 4iqqA-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.83A 4iqqB-2i53A:
undetectable		 4iqqB-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.81A 4iqqC-2i53A:
undetectable		 4iqqC-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 8 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 4iqqD-2i53A:
undetectable		 4iqqD-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i53 CYCLIN K
(Homo
sapiens) 		5 / 12 GLY A  96
TYR A  77
LEU A 102
HIS A  79
GLY A 104
 None
 0.96A 5d4uA-2i53A:
undetectable		 5d4uA-2i53A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i53 CYCLIN K
(Homo
sapiens) 		5 / 12 GLY A  96
TYR A  77
LEU A 102
HIS A  79
GLY A 104
 None
 0.95A 5d4uB-2i53A:
undetectable		 5d4uB-2i53A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i53 CYCLIN K
(Homo
sapiens) 		5 / 12 GLY A  96
TYR A  77
LEU A 102
HIS A  79
GLY A 104
 None
 0.94A 5d4uC-2i53A:
undetectable		 5d4uC-2i53A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2i53 CYCLIN K
(Homo
sapiens) 		5 / 12 GLY A  96
TYR A  77
LEU A 102
HIS A  79
GLY A 104
 None
 0.98A 5d4uD-2i53A:
undetectable		 5d4uD-2i53A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.90A 5h3aA-2i53A:
undetectable		 5h3aA-2i53A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 5nooA-2i53A:
undetectable		 5nooA-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 7 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 5nooB-2i53A:
undetectable		 5nooB-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2i53 CYCLIN K
(Homo
sapiens) 		4 / 8 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 5nooD-2i53A:
undetectable		 5nooD-2i53A:
21.32