SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		5 / 12 PHE A  63
LEU A  40
LEU A   7
GLU A 240
LEU A 239
 None
 1.20A 2bxfA-2i54A:
undetectable		 2bxfA-2i54A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		4 / 5 PHE A  67
ILE A  59
ASN A  84
PHE A  63
 None
 1.38A 3octA-2i54A:
undetectable		 3octA-2i54A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		5 / 11 PRO A 130
VAL A 128
TYR A 171
ILE A 111
ILE A 157
 None
 1.47A 3q5rA-2i54A:
0.0		 3q5rA-2i54A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		4 / 7 LEU A 105
PRO A 130
GLU A 159
TYR A 171
 None
 1.01A 4lb2A-2i54A:
undetectable		 4lb2A-2i54A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		3 / 3 ASP A  10
ASN A  70
SER A 210
 MG  A2002 (-2.8A)
None
None
 0.78A 4obwA-2i54A:
undetectable		 4obwA-2i54A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		5 / 12 LEU A   7
LEU A  40
GLY A  41
THR A 224
ILE A 218
 None
 1.33A 4oktA-2i54A:
undetectable		 4oktA-2i54A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		4 / 5 ILE A 157
PHE A 118
SER A 172
ASP A 147
 None
 1.42A 4rzvB-2i54A:
undetectable		 4rzvB-2i54A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		5 / 11 GLY A 213
VAL A  43
LEU A  15
LEU A   8
THR A  14
 None
 1.15A 4zmeA-2i54A:
undetectable		 4zmeA-2i54A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		3 / 3 ASN A 127
SER A 178
ARG A 140
 CIT  A3001 ( 4.5A)
CIT  A3001 (-3.0A)
CIT  A3001 (-3.8A)
 0.76A 5b2qA-2i54A:
undetectable		 5b2qA-2i54A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2i54 PHOSPHOMANNOMUTASE
(Leishmania
mexicana) 		4 / 7 GLY A 116
THR A 117
PHE A 118
SER A 178
 None
None
None
CIT  A3001 (-3.0A)
 0.67A 6jnhA-2i54A:
3.8		 6jnhA-2i54A:
25.12