SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLN A 169
GLY A 179
GLY A 177
VAL A 276
LEU A 274
 None
 1.12A 1jg2A-2i58A:
undetectable		 1jg2A-2i58A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLN A 218
ALA A 224
GLY A 225
ALA A 234
ILE A 260
 None
 1.21A 1kxhA-2i58A:
undetectable		 1kxhA-2i58A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A  16
TRP A 246
TYR A  65
TYR A 311
 None
 1.28A 1qvuA-2i58A:
undetectable		 1qvuA-2i58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ALA A 173
LEU A 170
GLY A 166
GLY A 277
 None
 0.77A 1rukH-2i58A:
undetectable
1rukL-2i58A:
undetectable		 1rukH-2i58A:
19.01
1rukL-2i58A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 185
LEU A 379
ASN A 380
LYS A 387
 None
 1.17A 2w98A-2i58A:
0.4
2w98B-2i58A:
undetectable		 2w98A-2i58A:
20.90
2w98B-2i58A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z77_D_NCAD200_0
(PUTATIVE STEROID
ISOMERASE)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ASP A 204
LEU A 186
LEU A 362
LEU A 379
MET A 208
 None
 1.41A 2z77D-2i58A:
0.0		 2z77D-2i58A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A 287
ASN A 108
VAL A  58
ILE A  64
LEU A  49
 None
 1.30A 3fl9C-2i58A:
undetectable		 3fl9C-2i58A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 383
PHE A 172
ALA A 182
THR A 176
 None
 1.11A 3t3sB-2i58A:
undetectable		 3t3sB-2i58A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A  16
GLY A 236
ASP A 237
ARG A 235
 None
 0.87A 5cdnA-2i58A:
undetectable
5cdnB-2i58A:
undetectable		 5cdnA-2i58A:
20.36
5cdnB-2i58A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 158
LEU A 362
PHE A 383
ILE A 194
PHE A 359
 None
 1.17A 5eskA-2i58A:
undetectable		 5eskA-2i58A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A  66
TYR A 100
SER A 245
ASN A 114
 None
 1.14A 5l1fC-2i58A:
undetectable		 5l1fC-2i58A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A  66
TYR A 100
SER A 317
ASN A 114
 None
 0.64A 5l1fC-2i58A:
undetectable		 5l1fC-2i58A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A 110
TYR A  96
SER A 245
ASN A 114
 None
 1.12A 5l1fC-2i58A:
undetectable		 5l1fC-2i58A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 THR A 275
ALA A 340
THR A 342
GLY A 277
ALA A 113
 None
 1.10A 5l66K-2i58A:
undetectable
5l66L-2i58A:
undetectable		 5l66K-2i58A:
19.95
5l66L-2i58A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 THR A 275
ALA A 340
THR A 342
GLY A 277
ALA A 113
 None
 1.10A 5l66Y-2i58A:
undetectable
5l66Z-2i58A:
undetectable		 5l66Y-2i58A:
19.95
5l66Z-2i58A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASN A 296
VAL A   6
HIS A 291
 None
 0.81A 6a5yD-2i58A:
undetectable		 6a5yD-2i58A:
12.63