SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2i5c PLECKSTRIN
(Homo
sapiens) 		4 / 6 GLU A 337
THR A 331
ALA A 329
LEU A 327
 None
 0.92A 1etb2-2i5cA:
undetectable		 1etb2-2i5cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2i5c PLECKSTRIN
(Homo
sapiens) 		4 / 8 GLU A 337
THR A 331
ALA A 329
LEU A 327
 None
 0.88A 1sn5C-2i5cA:
undetectable		 1sn5C-2i5cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2i5c PLECKSTRIN
(Homo
sapiens) 		5 / 12 ALA A 341
LEU A 275
LEU A 268
LEU A 327
LEU A 292
 None
 1.18A 1xdkB-2i5cA:
undetectable		 1xdkB-2i5cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2i5c PLECKSTRIN
(Homo
sapiens) 		4 / 8 GLU A 337
THR A 331
ALA A 329
LEU A 327
 None
 0.95A 4iizB-2i5cA:
undetectable		 4iizB-2i5cA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2i5c PLECKSTRIN
(Homo
sapiens) 		5 / 9 LEU A 275
LEU A 292
VAL A 244
ARG A 269
ALA A 345
 None
 1.41A 5g44A-2i5cA:
undetectable		 5g44A-2i5cA:
19.37