SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9H_A_RAPA108_1 (FKBP12.6)	2i5e	HYPOTHETICAL PROTEIN MM_2497 (Methanosarcina mazei)	5 / 12	GLU A 86 VAL A 88 ILE A 128 VAL A 116 ILE A 115	None	1.17A	1c9hA-2i5eA: undetectable	1c9hA-2i5eA: 17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_J_BEZJ5041_0 (CES1 PROTEIN)	2i5e	HYPOTHETICAL PROTEIN MM_2497 (Methanosarcina mazei)	4 / 4	GLY A 122 SER A 142 ILE A 115 HIS A 146	TRS A 302 (-3.6A) None None None	1.19A	1yajJ-2i5eA: undetectable	1yajJ-2i5eA: 17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WM3_A_NFLA1301_1 (NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1)	2i5e	HYPOTHETICAL PROTEIN MM_2497 (Methanosarcina mazei)	4 / 6	LEU A 178 PHE A 28 LEU A 31 ASP A 94	None	1.11A	2wm3A-2i5eA: 3.4	2wm3A-2i5eA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SFU_C_RBVC601_1 (RNA POLYMERASE)	2i5e	HYPOTHETICAL PROTEIN MM_2497 (Methanosarcina mazei)	5 / 11	ASP A 94 LEU A 95 THR A 123 ASN A 124 GLY A 118	None None None None TRS A 302 ( 4.5A)	1.23A	3sfuC-2i5eA: undetectable	3sfuC-2i5eA: 18.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C9H_A_RAPA108_1","FKBP12.6","2i5e","HYPOTHETICAL PROTEIN MM_2497","Methanosarcina mazei",5,"GLU A  86;VAL A  88;ILE A 128;VAL A 116;ILE A 115","None","1.17A","1c9hA-2i5eA:undetectable","1c9hA-2i5eA:17.96"],["1YAJ_J_BEZJ5041_0","CES1 PROTEIN","2i5e","HYPOTHETICAL PROTEIN MM_2497","Methanosarcina mazei",4,"GLY A 122;SER A 142;ILE A 115;HIS A 146","TRS A 302 (-3.6A);None;None;None","1.19A","1yajJ-2i5eA:undetectable","1yajJ-2i5eA:17.16"],["2WM3_A_NFLA1301_1","NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1","2i5e","HYPOTHETICAL PROTEIN MM_2497","Methanosarcina mazei",4,"LEU A 178;PHE A  28;LEU A  31;ASP A  94","None","1.11A","2wm3A-2i5eA:3.4","2wm3A-2i5eA:22.90"],["3SFU_C_RBVC601_1","RNA POLYMERASE","2i5e","HYPOTHETICAL PROTEIN MM_2497","Methanosarcina mazei",5,"ASP A  94;LEU A  95;THR A 123;ASN A 124;GLY A 118","None;None;None;None;TRS A 302 ( 4.5A)","1.23A","3sfuC-2i5eA:undetectable","3sfuC-2i5eA:18.43"]]