SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A 249
THR A 295
HIS A   8
LEU A  35
 None
 1.37A 1d4fC-2i5gA:
undetectable		 1d4fC-2i5gA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 135
GLN A 118
GLY A 128
GLY A 137
 None
 0.77A 1f5lA-2i5gA:
undetectable		 1f5lA-2i5gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.17A 1fohB-2i5gA:
undetectable		 1fohB-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.16A 1fohC-2i5gA:
undetectable		 1fohC-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 248
 None
 1.49A 1fohC-2i5gA:
undetectable		 1fohC-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.17A 1fohD-2i5gA:
undetectable		 1fohD-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.16A 1pn0A-2i5gA:
undetectable		 1pn0A-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.17A 1pn0B-2i5gA:
undetectable		 1pn0B-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.13A 1pn0C-2i5gA:
undetectable		 1pn0C-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 248
 None
 1.50A 1pn0C-2i5gA:
undetectable		 1pn0C-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.13A 1pn0D-2i5gA:
undetectable		 1pn0D-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 310
ILE A 247
THR A  36
 None
 0.85A 1rx3A-2i5gA:
undetectable		 1rx3A-2i5gA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 127
GLY A 128
THR A 165
ASP A 157
 None
 0.97A 2a1mA-2i5gA:
undetectable		 2a1mA-2i5gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 157
ILE A  18
VAL A  72
 None
 0.38A 2avvD-2i5gA:
undetectable		 2avvD-2i5gA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 192
SER A 180
GLY A 248
THR A 249
 None
 1.21A 2f7fA-2i5gA:
3.1		 2f7fA-2i5gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 323
VAL A 177
ASP A  15
 None
 0.70A 2fumD-2i5gA:
undetectable		 2fumD-2i5gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 264
ASP A 250
SER A 180
 None
 0.84A 2nxeA-2i5gA:
undetectable		 2nxeA-2i5gA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 264
ASP A 250
SER A 180
 None
 0.85A 2nxeB-2i5gA:
undetectable		 2nxeB-2i5gA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 8 ASP A 135
GLN A 118
VAL A 169
GLY A 128
GLY A 137
 None
 1.33A 2vinA-2i5gA:
undetectable		 2vinA-2i5gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 181
TRP A 316
ASP A 157
ILE A 116
 None
 0.95A 2xadD-2i5gA:
undetectable		 2xadD-2i5gA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 191
GLU A 133
TYR A 132
 None
 0.47A 2zmbA-2i5gA:
undetectable		 2zmbA-2i5gA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ARG A  31
ALA A  38
ILE A 247
GLY A 313
ILE A  12
 None
 0.97A 3ekxB-2i5gA:
undetectable		 3ekxB-2i5gA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 281
ASP A 250
ARG A 272
 None
 0.77A 3k13A-2i5gA:
7.3		 3k13A-2i5gA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A  93
TYR A 105
LEU A 158
 None
 0.78A 3sueB-2i5gA:
undetectable		 3sueB-2i5gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  41
HIS A 160
TYR A 121
LEU A 263
 None
 1.24A 4awuA-2i5gA:
6.1		 4awuA-2i5gA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  17
MET A 213
TYR A 179
 None
 0.66A 4p6xG-2i5gA:
undetectable		 4p6xG-2i5gA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  88
GLN A  84
ARG A  79
ILE A  78
VAL A  72
 None
 1.02A 4uw0A-2i5gA:
undetectable		 4uw0A-2i5gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 298
GLY A 210
ALA A 232
VAL A 240
VAL A 307
 None
 1.09A 4wnwB-2i5gA:
undetectable		 4wnwB-2i5gA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 167
GLU A 168
GLU A 198
ILE A 145
ASP A 135
 None
 1.27A 4xe5A-2i5gA:
undetectable		 4xe5A-2i5gA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  16
GLY A 248
THR A 249
ILE A  18
GLN A 118
 None
 1.27A 4zvmA-2i5gA:
undetectable
4zvmB-2i5gA:
undetectable		 4zvmA-2i5gA:
21.86
4zvmB-2i5gA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A  72
ALA A  81
ILE A  14
THR A  36
 None
 1.17A 5e4dB-2i5gA:
undetectable		 5e4dB-2i5gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 163
SER A 195
GLU A 197
GLU A 198
GLU A 189
 None
 1.36A 5iqeC-2i5gA:
undetectable		 5iqeC-2i5gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  92
VAL A 288
LEU A  35
GLY A 248
SER A 180
 None
 1.12A 5vooB-2i5gA:
6.6		 5vooB-2i5gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  92
VAL A 288
LEU A  35
GLY A 248
SER A 180
 None
 1.14A 5vooD-2i5gA:
5.0		 5vooD-2i5gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  92
VAL A 288
LEU A  35
GLY A 248
SER A 180
 None
 1.16A 5vooE-2i5gA:
6.5		 5vooE-2i5gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  92
VAL A 288
LEU A  35
GLY A 248
SER A 180
 None
 1.13A 5vooF-2i5gA:
4.8		 5vooF-2i5gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  92
VAL A 288
LEU A  35
GLY A 248
SER A 180
 None
 1.11A 5vopB-2i5gA:
6.3		 5vopB-2i5gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.01A 6ebpC-2i5gA:
undetectable		 6ebpC-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.04A 6ebzA-2i5gA:
undetectable		 6ebzA-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.02A 6ebzB-2i5gA:
undetectable		 6ebzB-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.01A 6ebzC-2i5gA:
undetectable		 6ebzC-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.07A 6ebzD-2i5gA:
undetectable		 6ebzD-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2i5g AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 294
THR A 297
ARG A 301
VAL A 311
ILE A 233
 None
 1.28A 6ef6A-2i5gA:
undetectable		 6ef6A-2i5gA:
20.16