SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 2i5h HYPOTHETICAL PROTEIN
AF1531
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 107
GLU A  16
LEU A 100
ILE A 104
TYR A 115
 None
 0.94A 3cd2A-2i5hA:
undetectable		 3cd2A-2i5hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2i5h HYPOTHETICAL PROTEIN
AF1531
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 175
MET A 143
LYS A 140
GLY A 139
 None
 1.23A 3sj0X-2i5hA:
undetectable		 3sj0X-2i5hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2i5h HYPOTHETICAL PROTEIN
AF1531
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 107
ARG A  86
LEU A 100
ILE A 104
TYR A 115
 None
 1.05A 4m2xC-2i5hA:
undetectable		 4m2xC-2i5hA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2i5h HYPOTHETICAL PROTEIN
AF1531
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 150
ILE A 161
PHE A 119
 None
 0.73A 5kirA-2i5hA:
undetectable		 5kirA-2i5hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2i5h HYPOTHETICAL PROTEIN
AF1531
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 130
ARG A 150
ILE A 147
 None
 0.87A 6fgdA-2i5hA:
undetectable		 6fgdA-2i5hA:
18.47