SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 11 SER A  50
ARG A 121
GLY A  14
THR A  20
GLN A  21
 None
 1.36A 1jr1A-2i5iA:
3.2		 1jr1A-2i5iA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		3 / 3 ASP A  12
THR A  36
GLU A 209
 None
 0.73A 1pj7A-2i5iA:
undetectable		 1pj7A-2i5iA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 10 ARG A 231
ILE A  60
GLY A  61
VAL A  19
ILE A  23
 None
 0.95A 1sdtA-2i5iA:
undetectable		 1sdtA-2i5iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 ILE A 113
ILE A 126
GLY A  61
ILE A  60
 None
 0.72A 1sh9A-2i5iA:
undetectable		 1sh9A-2i5iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 12 ALA A  10
ILE A  23
VAL A  19
ALA A  18
MET A 229
 None
 1.01A 1uduB-2i5iA:
undetectable		 1uduB-2i5iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 4 LEU A 180
SER A 203
LEU A 197
LEU A   6
 None
 1.11A 1yajA-2i5iA:
undetectable		 1yajA-2i5iA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 12 MET A 262
GLU A 209
ILE A   7
TYR A 257
TYR A 170
 None
 1.46A 2mjiA-2i5iA:
undetectable		 2mjiA-2i5iA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		3 / 3 LEU A 260
TYR A 257
GLY A  61
 None
 0.64A 2ocuA-2i5iA:
undetectable		 2ocuA-2i5iA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 4 SER A  41
PRO A  42
PHE A  44
PRO A  39
 None
 1.34A 3bjwA-2i5iA:
0.0		 3bjwA-2i5iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 4 SER A  41
PRO A  42
PHE A  44
PRO A  39
 None
 1.34A 3bjwG-2i5iA:
0.0		 3bjwG-2i5iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 4 SER A  41
PRO A  42
PHE A  44
PRO A  39
 None
 1.36A 3bjwD-2i5iA:
0.0		 3bjwD-2i5iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 ALA A 255
ILE A   7
ASN A 256
PRO A 176
 None
 0.97A 3fxrA-2i5iA:
undetectable		 3fxrA-2i5iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 TYR A 227
VAL A  19
ILE A  23
LEU A 238
 None
 0.83A 4jq1B-2i5iA:
2.9		 4jq1B-2i5iA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 11 THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.06A 5d0xV-2i5iA:
undetectable		 5d0xV-2i5iA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 12 THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.09A 5l5zH-2i5iA:
undetectable
5l5zI-2i5iA:
undetectable		 5l5zH-2i5iA:
23.81
5l5zI-2i5iA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 12 THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.09A 5l5zV-2i5iA:
undetectable
5l5zW-2i5iA:
undetectable		 5l5zV-2i5iA:
23.81
5l5zW-2i5iA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 10 ALA A  10
THR A  35
CYH A 212
GLY A  22
ALA A  26
 None
 1.11A 5lf3H-2i5iA:
undetectable
5lf3I-2i5iA:
undetectable		 5lf3H-2i5iA:
22.39
5lf3I-2i5iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 10 THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.05A 5lf3H-2i5iA:
undetectable
5lf3I-2i5iA:
undetectable		 5lf3H-2i5iA:
22.39
5lf3I-2i5iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		6 / 11 ALA A  10
THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.08A 5lf7H-2i5iA:
undetectable
5lf7I-2i5iA:
undetectable		 5lf7H-2i5iA:
22.39
5lf7I-2i5iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		6 / 11 ALA A  10
THR A  35
CYH A 212
ALA A 215
GLY A  22
ALA A  26
 None
 1.08A 5lf7V-2i5iA:
undetectable
5lf7W-2i5iA:
undetectable		 5lf7V-2i5iA:
22.39
5lf7W-2i5iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 6 ASP A  11
ASP A  12
HIS A  63
HIS A 213
 None
 0.48A 5ncdA-2i5iA:
10.3
5ncdD-2i5iA:
10.6		 5ncdA-2i5iA:
23.24
5ncdD-2i5iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 6 ASP A  11
ASP A  12
HIS A 129
HIS A 213
 None
 0.91A 5ncdA-2i5iA:
10.3
5ncdD-2i5iA:
10.6		 5ncdA-2i5iA:
23.24
5ncdD-2i5iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 6 ASP A  11
ASP A  12
HIS A  63
HIS A 129
HIS A 213
 None
 0.82A 5ncdB-2i5iA:
10.5
5ncdC-2i5iA:
10.6		 5ncdB-2i5iA:
23.24
5ncdC-2i5iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 ASP A  11
ASP A  12
HIS A  63
HIS A 213
 None
 0.49A 5nekB-2i5iA:
11.5		 5nekB-2i5iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 ASP A  11
ASP A  12
HIS A 129
HIS A 213
 None
 0.90A 5nekB-2i5iA:
11.5		 5nekB-2i5iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 8 ASP A  11
ASP A  12
HIS A  63
HIS A 213
 None
 0.58A 5nekD-2i5iA:
11.2		 5nekD-2i5iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		4 / 6 ASP A  11
ASP A  12
HIS A  63
HIS A 213
 None
 0.45A 5nelA-2i5iA:
10.5
5nelD-2i5iA:
10.6		 5nelA-2i5iA:
23.24
5nelD-2i5iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		3 / 3 HIS A  63
HIS A 129
HIS A 130
 None
 0.70A 5oexA-2i5iA:
undetectable		 5oexA-2i5iA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		3 / 3 ARG A 250
PHE A 183
LEU A 194
 None
 0.95A 5x1bC-2i5iA:
undetectable		 5x1bC-2i5iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2i5i UPF0249 PROTEIN
EF_3048
(Enterococcus
faecalis) 		5 / 12 ASP A  12
ALA A  47
GLY A  22
ARG A 231
ASP A 218
 None
 1.00A 6clxA-2i5iA:
undetectable		 6clxA-2i5iA:
21.51