SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 421
PHE A 433
PHE A 427
ILE A 440
 None
 1.15A 2hjhA-2i5kA:
undetectable		 2hjhA-2i5kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 458
ILE A 479
ILE A 496
ASP A 460
 None
 0.81A 3a7eA-2i5kA:
undetectable		 3a7eA-2i5kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 461
LEU A 457
ILE A 479
VAL A 467
 None
 0.96A 4a9kB-2i5kA:
undetectable		 4a9kB-2i5kA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 317
GLY A 365
PHE A 220
ILE A 323
 None
 0.92A 4fglC-2i5kA:
undetectable		 4fglC-2i5kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 134
ILE A 126
ASP A 166
 None
 0.73A 5cswB-2i5kA:
undetectable		 5cswB-2i5kA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 479
LEU A 394
HIS A 448
VAL A 467
 None
 1.11A 5jmnB-2i5kA:
undetectable		 5jmnB-2i5kA:
19.16