SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		4 / 8 TYR A 139
SER A 136
ILE A 176
SER A  61
 None
 1.12A 2xz5B-2i5tA:
undetectable
2xz5E-2i5tA:
undetectable		 2xz5B-2i5tA:
22.52
2xz5E-2i5tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		4 / 8 TYR A  19
VAL A 107
ILE A 108
ILE A  71
 None
 0.67A 3uqbA-2i5tA:
undetectable		 3uqbA-2i5tA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		5 / 10 TYR A  22
GLY A  23
SER A  24
TYR A 105
TYR A 125
 None
 0.69A 5hwkA-2i5tA:
11.0		 5hwkA-2i5tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		5 / 10 TYR A  22
GLY A  23
SER A  24
TYR A 105
TYR A 125
 None
 0.68A 5hwkB-2i5tA:
11.0		 5hwkB-2i5tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		5 / 9 ILE A 163
PRO A 165
ILE A 180
TYR A 139
LEU A  51
 None
 1.29A 5iepA-2i5tA:
undetectable		 5iepA-2i5tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		5 / 12 GLY A  23
VAL A  82
GLN A  97
ASN A 150
GLY A 146
 None
 1.11A 6gneA-2i5tA:
undetectable		 6gneA-2i5tA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2i5t PROTEIN C7ORF24
(Homo
sapiens) 		5 / 12 GLY A  23
VAL A  82
GLN A  97
ASN A 150
GLY A 146
 None
 1.12A 6gneB-2i5tA:
undetectable		 6gneB-2i5tA:
17.14