SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 10 VAL A  55
LEU A  84
PRO A  58
VAL A  63
GLU A  65
 None
 1.20A 1fdwA-2i6dA:
2.1		 1fdwA-2i6dA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 CYH A 247
LEU A 246
LEU A 221
ILE A 199
ILE A 126
 None
 1.39A 1hzeA-2i6dA:
undetectable
1hzeB-2i6dA:
undetectable		 1hzeA-2i6dA:
17.39
1hzeB-2i6dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 ILE A 126
CYH A 247
LEU A 246
LEU A 221
ILE A 199
 None
 1.39A 1hzeA-2i6dA:
undetectable
1hzeB-2i6dA:
undetectable		 1hzeA-2i6dA:
17.39
1hzeB-2i6dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 10 CYH A 247
LEU A 246
LEU A 221
ILE A 199
ILE A 126
 None
 1.41A 1i18A-2i6dA:
0.6
1i18B-2i6dA:
0.6		 1i18A-2i6dA:
17.39
1i18B-2i6dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 10 ILE A 126
CYH A 247
LEU A 246
LEU A 221
ILE A 199
 None
 1.41A 1i18A-2i6dA:
0.6
1i18B-2i6dA:
0.6		 1i18A-2i6dA:
17.39
1i18B-2i6dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 12 LEU A 166
GLY A 134
GLY A 107
THR A 162
LEU A 104
 None
 1.01A 1liiA-2i6dA:
2.2		 1liiA-2i6dA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		7 / 12 LEU A 181
GLY A 203
GLY A 208
ILE A 223
LEU A 237
VAL A 239
ALA A 242
 None
 0.57A 1v2xA-2i6dA:
17.2		 1v2xA-2i6dA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		7 / 12 LEU A 181
GLY A 208
ILE A 223
SER A 236
LEU A 237
VAL A 239
ALA A 242
 None
 0.86A 1v2xA-2i6dA:
17.2		 1v2xA-2i6dA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 11 GLY A 203
GLY A 208
ILE A 223
LEU A 237
ALA A 242
 None
 0.49A 1x7pA-2i6dA:
25.9
1x7pB-2i6dA:
25.6		 1x7pA-2i6dA:
30.45
1x7pB-2i6dA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 10 GLY A 203
GLY A 208
ILE A 223
LEU A 237
ALA A 242
 None
 0.46A 1x7pA-2i6dA:
25.9
1x7pB-2i6dA:
25.6		 1x7pA-2i6dA:
30.45
1x7pB-2i6dA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_A_ADNA1588_1
(ACSD)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 10 LEU A 131
PRO A 156
ILE A 199
THR A 102
LEU A 118
 None
 1.39A 2w03A-2i6dA:
0.0		 2w03A-2i6dA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 ALA A 179
GLY A 203
GLY A 208
LEU A 237
ALA A 242
 None
 0.86A 2z0yA-2i6dA:
12.5		 2z0yA-2i6dA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 ALA A 179
GLY A 203
GLY A 208
LEU A 237
ALA A 242
 None
 0.75A 2z0yB-2i6dA:
11.8		 2z0yB-2i6dA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 8 ALA A 244
THR A 116
ILE A 117
THR A 120
 None
 0.55A 3bpxA-2i6dA:
undetectable
3bpxB-2i6dA:
undetectable		 3bpxA-2i6dA:
20.08
3bpxB-2i6dA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 11 GLY A 203
GLY A 208
ILE A 223
LEU A 237
VAL A 239
ALA A 242
 None
 0.34A 3dcmX-2i6dA:
12.5		 3dcmX-2i6dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 11 GLY A 203
GLY A 208
ILE A 245
LEU A 237
VAL A 239
ALA A 242
 None
 1.44A 3dcmX-2i6dA:
12.5		 3dcmX-2i6dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 12 ILE A 117
VAL A 239
ILE A 245
VAL A 129
ARG A 119
 None
 1.20A 3fpjB-2i6dA:
undetectable		 3fpjB-2i6dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 12 ASN A 113
GLY A 203
GLY A 208
ILE A 223
ASN A 238
VAL A 239
 ACY  A 301 (-4.0A)
None
None
None
None
None
 0.44A 3nk7A-2i6dA:
22.0		 3nk7A-2i6dA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 12 ASN A 113
GLY A 203
GLY A 208
ILE A 223
LEU A 237
VAL A 239
 ACY  A 301 (-4.0A)
None
None
None
None
None
 0.47A 3nk7B-2i6dA:
22.8		 3nk7B-2i6dA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 6 LEU A 101
ALA A 244
THR A 120
LEU A 202
 None
 0.96A 3t3zA-2i6dA:
undetectable		 3t3zA-2i6dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 6 LEU A 101
ALA A 244
THR A 120
LEU A 202
 None
 0.97A 3t3zB-2i6dA:
undetectable		 3t3zB-2i6dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 6 LEU A 101
ALA A 244
THR A 120
LEU A 202
 None
 0.95A 3t3zD-2i6dA:
undetectable		 3t3zD-2i6dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 12 GLY A 132
GLY A 134
ARG A 207
VAL A 213
ALA A 214
 None
 1.20A 3t7vA-2i6dA:
undetectable		 3t7vA-2i6dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 12 LEU A 166
GLY A 134
GLY A 107
THR A 162
LEU A 104
 None
 1.00A 3vasA-2i6dA:
2.7		 3vasA-2i6dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 8 ILE A   7
ILE A  75
PHE A  72
VAL A  64
GLY A  47
 None
 1.25A 4ac9C-2i6dA:
2.4		 4ac9C-2i6dA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 4 LEU A 202
ILE A 217
GLY A 203
PHE A 180
 None
 0.91A 4dc3A-2i6dA:
2.4		 4dc3A-2i6dA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 8 ARG A 207
SER A 140
VAL A 143
GLY A 134
 None
 0.96A 4mk4A-2i6dA:
3.1		 4mk4A-2i6dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 5 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.03A 4w5oA-2i6dA:
undetectable		 4w5oA-2i6dA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 LEU A 202
GLY A 203
ILE A 223
LEU A 237
VAL A 239
 None
 0.91A 4x3mB-2i6dA:
24.6		 4x3mB-2i6dA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 9 LEU A 202
ILE A 223
SER A 236
LEU A 237
VAL A 239
 None
 0.93A 4x3mB-2i6dA:
24.6		 4x3mB-2i6dA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 5 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.00A 4z4cA-2i6dA:
undetectable		 4z4cA-2i6dA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 5 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.01A 4z4dA-2i6dA:
undetectable		 4z4dA-2i6dA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 5 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.00A 4z4eA-2i6dA:
undetectable		 4z4eA-2i6dA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		5 / 12 THR A 243
ALA A 242
ILE A 209
GLY A 178
LEU A 200
 None
 1.16A 5gs4A-2i6dA:
undetectable		 5gs4A-2i6dA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		7 / 12 LEU A 181
GLY A 203
GLY A 208
ILE A 223
SER A 236
LEU A 237
ALA A 242
 None
 0.82A 5l0zA-2i6dA:
26.0		 5l0zA-2i6dA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 10 GLY A 203
GLY A 208
ILE A 223
SER A 236
LEU A 237
ALA A 242
 None
 0.65A 5l0zB-2i6dA:
8.0		 5l0zB-2i6dA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		6 / 10 LEU A 181
GLY A 203
GLY A 208
ILE A 223
LEU A 237
ALA A 242
 None
 0.69A 5l0zB-2i6dA:
8.0		 5l0zB-2i6dA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 7 GLY A 203
GLY A 208
LEU A 237
ALA A 242
 None
 0.65A 5o96C-2i6dA:
13.0		 5o96C-2i6dA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Porphyromonas
gingivalis) 		4 / 6 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.01A 5t7bA-2i6dA:
2.3		 5t7bA-2i6dA:
15.72