SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 4 HIS A  23
LEU A  36
LEU A 219
LEU A  79
 None
 1.23A 1a4lD-2i6eA:
undetectable		 1a4lD-2i6eA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 5 ARG A 106
ALA A 146
ALA A 136
GLU A 134
 None
 1.21A 1e7cA-2i6eA:
undetectable		 1e7cA-2i6eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 9 GLU A 134
LEU A  95
LEU A 104
ARG A 106
ALA A 108
 None
 1.37A 2bxcB-2i6eA:
undetectable		 2bxcB-2i6eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY A 150
ALA A 108
LEU A 109
THR A 188
LEU A 101
 None
 0.99A 2nyuB-2i6eA:
undetectable		 2nyuB-2i6eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 4 LEU A 190
ARG A 125
LEU A 124
ALA A 118
 None
 1.11A 3b9mA-2i6eA:
undetectable		 3b9mA-2i6eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.07A 3e22B-2i6eA:
undetectable		 3e22B-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.07A 3e22D-2i6eA:
undetectable		 3e22D-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		3 / 3 PRO A  89
ASN A 258
HIS A 254
 None
None
SO4  A 701 (-3.8A)
 0.98A 4ma3H-2i6eA:
undetectable
4ma3L-2i6eA:
undetectable		 4ma3H-2i6eA:
22.52
4ma3L-2i6eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.07A 4x1kD-2i6eA:
undetectable		 4x1kD-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.08A 4x20D-2i6eA:
undetectable		 4x20D-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 10 PRO A  89
ALA A 191
PHE A 204
VAL A  84
PRO A  29
 None
 1.39A 5m0oA-2i6eA:
undetectable		 5m0oA-2i6eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
ARG A 106
GLY A 150
TYR A 148
 None
 1.43A 5x80A-2i6eA:
undetectable
5x80B-2i6eA:
undetectable		 5x80A-2i6eA:
23.33
5x80B-2i6eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A 165
SER A 142
LEU A 144
GLU A 141
ILE A 185
 None
 1.00A 6fdyU-2i6eA:
undetectable		 6fdyU-2i6eA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 GLU A 121
ARG A 125
VAL A 279
PRO A 280
 None
 1.32A 6fgdA-2i6eA:
undetectable		 6fgdA-2i6eA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2i6e HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LEU A  54
GLY A  57
ARG A 210
ARG A  18
 None
 1.12A 6gtqB-2i6eA:
undetectable
6gtqD-2i6eA:
undetectable		 6gtqB-2i6eA:
22.37
6gtqD-2i6eA:
10.14