SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A  81
LEU A  85
LYS A   1
GLY A  10
 None
 1.08A 1os6A-2i6jA:
undetectable		 1os6A-2i6jA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		4 / 6 MET A  82
ARG A   5
PRO A  73
GLY A 104
 None
 1.45A 3aqiA-2i6jA:
2.6		 3aqiA-2i6jA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		4 / 6 TRP A  45
ILE A  41
VAL A  97
HIS A  95
 None
None
PO4  A2902 ( 4.4A)
None
 1.16A 3deuA-2i6jA:
undetectable		 3deuA-2i6jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		4 / 5 TRP A  45
ILE A  41
VAL A  97
HIS A  95
 None
None
PO4  A2902 ( 4.4A)
None
 1.20A 3deuB-2i6jA:
0.0		 3deuB-2i6jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  72
ILE A 106
ILE A  65
LEU A  79
VAL A 146
 None
 1.23A 3fpjB-2i6jA:
undetectable		 3fpjB-2i6jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A  94
LEU A  35
TYR A 110
GLY A  11
GLY A  99
 None
 1.13A 3ls4H-2i6jA:
undetectable		 3ls4H-2i6jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A 113
VAL A 119
ILE A 123
GLY A 104
VAL A 146
ILE A 112
 None
 1.26A 3nu5A-2i6jA:
undetectable		 3nu5A-2i6jA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A 113
VAL A 119
ILE A 123
GLY A 104
VAL A 146
ILE A 112
 None
 1.33A 4dqfA-2i6jA:
undetectable		 4dqfA-2i6jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		3 / 3 ALA A 122
GLN A 139
GLY A  71
 None
 0.56A 4odoC-2i6jA:
undetectable		 4odoC-2i6jA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A  55
LEU A  93
ILE A  67
GLN A  77
 None
 0.94A 5ljbA-2i6jA:
undetectable		 5ljbA-2i6jA:
25.43