SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2i6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 12 LEU A 136
ASN A  76
LEU A 137
LEU A 115
MET A 225
 None
 1.24A 1a28B-2i6lA:
undetectable		 1a28B-2i6lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 12 LEU A 297
ARG A 304
PHE A 232
ASP A 255
VAL A 251
 None
 1.42A 2vavH-2i6lA:
1.6		 2vavH-2i6lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 5 ALA A 218
GLY A 139
LYS A 141
HIS A 144
 None
 1.32A 2yldA-2i6lA:
2.1		 2yldA-2i6lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 5 ALA A 218
GLY A 139
LYS A 141
HIS A 144
 None
 1.08A 2ylgA-2i6lA:
undetectable		 2ylgA-2i6lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 12 LEU A 297
ALA A 289
ILE A 285
LEU A 231
ILE A 221
 None
 1.01A 3adxB-2i6lA:
undetectable		 3adxB-2i6lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 6 VAL A  34
LYS A  49
VAL A  78
ILE A 106
 None
 0.65A 3mssD-2i6lA:
23.0		 3mssD-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 9 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.81A 3zosA-2i6lA:
21.8		 3zosA-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 9 ILE A  68
LEU A  72
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.83A 3zosB-2i6lA:
21.9		 3zosB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 5 LYS A  49
LEU A  72
TYR A 110
MET A 111
 None
 1.12A 4bkjB-2i6lA:
22.0		 4bkjB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 5 VAL A  34
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.50A 4c8bA-2i6lA:
21.7		 4c8bA-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		3 / 3 TYR A 110
MET A 111
ILE A  77
 None
 0.76A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		3 / 3 TYR A 110
MET A 111
ILE A 169
 None
 0.29A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 12 ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.48A 4rzvA-2i6lA:
7.3		 4rzvA-2i6lA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
GLY A 173
 None
 1.42A 4rzvB-2i6lA:
22.3		 4rzvB-2i6lA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 10 VAL A  34
GLU A  65
LEU A  72
ILE A  77
TYR A 110
ILE A 169
 None
 0.86A 4u0iA-2i6lA:
22.0		 4u0iA-2i6lA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 10 VAL A  34
LEU A  72
ILE A  77
VAL A  78
TYR A 110
ILE A 169
 None
 0.79A 4u0iA-2i6lA:
22.0		 4u0iA-2i6lA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.77A 4xv2A-2i6lA:
23.4		 4xv2A-2i6lA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		5 / 12 ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.66A 4xv2B-2i6lA:
23.6		 4xv2B-2i6lA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.83A 5cswA-2i6lA:
22.8		 5cswA-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.81A 5cswB-2i6lA:
22.7		 5cswB-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A 106
TYR A 110
GLY A 173
 None
 1.10A 5hesB-2i6lA:
21.7		 5hesB-2i6lA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.78A 5hieA-2i6lA:
3.2		 5hieA-2i6lA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.79A 5hieB-2i6lA:
7.5		 5hieB-2i6lA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.78A 5hieD-2i6lA:
22.9		 5hieD-2i6lA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 7 LEU A  72
VAL A  78
ILE A  83
VAL A  80
 None
 1.07A 5jh7C-2i6lA:
undetectable		 5jh7C-2i6lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 5 ALA A 218
GLY A 139
LYS A 141
HIS A 144
 None
 1.13A 5jliA-2i6lA:
2.0		 5jliA-2i6lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 5 ALA A 218
GLY A 139
LYS A 141
HIS A 144
 None
 1.16A 5jt4A-2i6lA:
2.1		 5jt4A-2i6lA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		6 / 12 ALA A  47
LYS A  49
GLU A  65
VAL A  78
PHE A 159
GLY A 170
 None
 0.48A 5vcvA-2i6lA:
25.7		 5vcvA-2i6lA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 8 GLN A 135
ILE A  77
GLN A 108
ASP A 214
 None
 1.00A 5vlmH-2i6lA:
undetectable		 5vlmH-2i6lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens) 		4 / 4 VAL A  78
GLY A 170
ASP A 171
ASP A 114
 None
 1.10A 6cjkC-2i6lA:
undetectable		 6cjkC-2i6lA:
19.82